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Table 1 Input variables and associated confidence intervals and ranges used in the deterministic and probabilistic sensitivity analysis for the cost-effectiveness evaluation of vector control strategies in Mopeia, Mozambique

From: Cost and cost-effectiveness of indoor residual spraying with pirimiphos-methyl in a high malaria transmission district of Mozambique with high access to standard insecticide-treated nets

Inputs Likeliest (Low–high) Probability distribution Source
Costs estimates (US$)
 IRS cost per person protected (Min–Max) 8.26 (7.25–9.27) Gamma Project data
Health system costs (IQR)
 HS—uncomplicated malaria 4.34 (4.32–4.35) Gamma [26]
 HS—severe malaria 36.97 (18.03–44.09) Gamma [26]
Household costs (all ages) (IQR)
 Uncomplicated malaria—HH direct cost 0.74 (0.05–0.19) Gamma [26]
 Uncomplicated malaria—HH indirect cost 16.67 (0.00–22.38) Gamma [26]
 Severe malaria—HH direct cost 3.54 (0.60–6.31) Gamma [26]
 Severe malaria—HH indirect cost 154.30 (31.45–87.71) Gamma [26]
Household costs (children U5) (IQR)
 Uncomplicated malaria—HH direct cost 0.92 (0.00–1.05) Gamma [26]
 Uncomplicated malaria—HH indirect cost 7.23 (0.00–5.90) Gamma [26]
 Severe malaria—HH direct cost 4.68 (1.99–6.31) Gamma [26]
 Severe malaria—HH indirect cost 61.23 (47.17–71.60) Gamma [26]
DALYs
 Discount rate (range) 0.03 (0.00–0.05) Point estimate Assumption
 Average age (all ages) 15 - Point estimate [21]
 Average age (children U5) 1 - Point estimate [22]
 Life expectancy at birth (95% CI) 57.07 (49.73–64.61) Lognormal [23]
 Length of disability: uncomplicated malaria (range) 0.01096 (0.00548–0.01644) Gamma Assumption
 Length of disability: severe malaria (range) 0.02739 (0.02054–0.03424) Gamma Assumption
 Disability weight: uncomplicated malaria (range) 0.051 (0.032–0.074) Lognormal [27]
 Disability weight: severe malaria (range) 0.133 (0.088–0.190) Lognormal [27]
Effects measurement
 % malaria cases severe (range) 0.00517 (0.00259–0.00776) Beta [22]
Malaria infection incidence (95% CI)
 Incidence rate ratio—health facility-based (all ages) 0.78 (0.77–0.79) Lognormal [22]
 Incidence rate ratio—health facility-based (children U5) 0.76 (0.75–0.78) Lognormal [22]
 Incidence rate ratio—community-based (children U5) 0.82 (0.79–0.86) Lognormal [22]
Malaria prevalence in 2018 (95% CI)
 Odds ratio (all ages) 0.70 (0.49–1.00) Lognormal [22]
 Odds ratio (children U5) 0.54 (0.31–0.92) Lognormal [22]
Mortality estimates (per 10,000 individuals) (range)
 Case fatality rate malaria (all ages) 0.000873 (0.000655–0.001091) Beta [24]
 Case fatality rate malaria (children under five) 0.005205 (0.003904–0.006506) Beta [24]
 Non-malaria mortality rate 0.0116 (0.0058–0.0174) Beta [25]
Others (US$)
 Threshold cost-effectiveness (3 times 2018 GDPpc) 1470.60 - Point estimate [35]
  1. Children U5 children under five years of age, CI confidence interval, DALY disability-adjusted life-year, GDPpc gross domestic product per capita, HH household, HS health system, IQR inter-quartile range, IRS indoor residual spraying