Table 1 Input variables and associated confidence intervals and ranges used in the deterministic and probabilistic sensitivity analysis for the cost-effectiveness evaluation of vector control strategies in Mopeia, Mozambique

Costs estimates (US$)

 IRS cost per person protected (Min–Max)

8.26

(7.25–9.27)

Gamma

Project data

Health system costs (IQR)

 HS—uncomplicated malaria

4.34

(4.32–4.35)

Gamma

[26]

 HS—severe malaria

36.97

(18.03–44.09)

Gamma

[26]

Household costs (all ages) (IQR)

 Uncomplicated malaria—HH direct cost

0.74

(0.05–0.19)

Gamma

[26]

 Uncomplicated malaria—HH indirect cost

16.67

(0.00–22.38)

Gamma

[26]

 Severe malaria—HH direct cost

3.54

(0.60–6.31)

Gamma

[26]

 Severe malaria—HH indirect cost

154.30

(31.45–87.71)

Gamma

[26]

Household costs (children U5) (IQR)

 Uncomplicated malaria—HH direct cost

0.92

(0.00–1.05)

Gamma

[26]

 Uncomplicated malaria—HH indirect cost

7.23

(0.00–5.90)

Gamma

[26]

 Severe malaria—HH direct cost

4.68

(1.99–6.31)

Gamma

[26]

 Severe malaria—HH indirect cost

61.23

(47.17–71.60)

Gamma

[26]

DALYs

 Discount rate (range)

0.03

(0.00–0.05)

Point estimate

Assumption

 Average age (all ages)

15

-

Point estimate

[21]

 Average age (children U5)

1

-

Point estimate

[22]

 Life expectancy at birth (95% CI)

57.07

(49.73–64.61)

Lognormal

[23]

 Length of disability: uncomplicated malaria (range)

0.01096

(0.00548–0.01644)

Gamma

Assumption

 Length of disability: severe malaria (range)

0.02739

(0.02054–0.03424)

Gamma

Assumption

 Disability weight: uncomplicated malaria (range)

0.051

(0.032–0.074)

Lognormal

[27]

 Disability weight: severe malaria (range)

0.133

(0.088–0.190)

Lognormal

[27]

Effects measurement

 % malaria cases severe (range)

0.00517

(0.00259–0.00776)

Beta

[22]

Malaria infection incidence (95% CI)

 Incidence rate ratio—health facility-based (all ages)

0.78

(0.77–0.79)

Lognormal

[22]

 Incidence rate ratio—health facility-based (children U5)

0.76

(0.75–0.78)

Lognormal

[22]

 Incidence rate ratio—community-based (children U5)

0.82

(0.79–0.86)

Lognormal

[22]

Malaria prevalence in 2018 (95% CI)

 Odds ratio (all ages)

0.70

(0.49–1.00)

Lognormal

[22]

 Odds ratio (children U5)

0.54

(0.31–0.92)

Lognormal

[22]

Mortality estimates (per 10,000 individuals) (range)

 Case fatality rate malaria (all ages)

0.000873

(0.000655–0.001091)

Beta

[24]

 Case fatality rate malaria (children under five)

0.005205

(0.003904–0.006506)

Beta

[24]

 Non-malaria mortality rate

0.0116

(0.0058–0.0174)

Beta

[25]

Others (US$)

 Threshold cost-effectiveness (3 times 2018 GDPpc)

1470.60

-

Point estimate

[35]