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Table 2 Prevalence and density of P. vivax at baseline and endpoint

From: Gametocyte carriage of Plasmodium falciparum (pfs25) and Plasmodium vivax (pvs25) during mass screening and treatment in West Timor, Indonesia: a longitudinal prospective study

 

Baseline

Endpoint

p value

OR/GMR (95%CI)

Parasite prevalence

 By microscopy

43/811 (5%)a

35/740 (5%)b

0.643

0.89 (0.54–1.44)

 By PCR

183/811 (23%)

135/740 (18%)

0.038*

0.77 (0.59–0.99)*

 By either test

192/811 (24%)

142/740 (19%)

0.035*

0.77 (0.59–0.98)*

 Median parasitaemia/µL (IQR) (microscopy)

112 (48–1000)

80 (16–1080)

0.832

 

 Median 18S copies/µL (IQR) (qPCR) (n baseline = 115, endpoint = 74)

192.2 (60.6–605.2)

177.7 (72.7–1535.0)

0.719

 

Gametocyte prevalence

 By microscopy

9/811 (1.1%)

14/740 (1.9%)

0.215

1.72 (0.69–4.53)

 By pvs25

49/744 (7%)

39/704 (5%)

0.442

0.83 (0.52–1.31)

 By either test

49/744 (7%)

39/704 (5%)

0.442

0.83 (0.52–1.31)

Gametocyte density (per μL)

 By microscopy (median) (IQR)

160 (28–200)

64 (32–170)

0.516

 

 By pvs25 (geometric mean) (95%CI)

56.4 (23.8–134.0)

65.6 (26.5–162.2)

0.810

0.9 (0.2–3.0)

  1. OR odds ratio, GMR geometric mean ratio
  2. aNine and bseven subjects were not confirmed by PCR during baseline and endpoint, respectively. This is presumably due to degraded DNA and possible LM false positive as 11 of 16 (69%) showed negative microscopy during cross check.
  3. *p < 0.05