Table 3 Sensitivity and specificity of Pvr47 and COX1 targets to detect P. vivax

P. vivax infection detected by microscopy & PCR

71.4%

95 CI 47.7–87.8%

100.00%

95 CI 80.8–100%

52.4%

95 CI 30.3–73.6%

81.0%

95 CI 57.42–93.71%

n = 21

n = 15

n = 21

n = 11

n = 17

P. vivax submicroscopic infection detected only by PCR

36.1%

95 CI 26.1–47.5%

86.8%

95 CI 77.1–92.9%

22.9%

95 CI 14.7–33.7%

36.1%

95 CI 26.1%–47.5%

n = 83

n = 30

n = 72

n = 19

n = 30

Non P. vivax infection detected by microscopy & PCR

95.7%

95 CI 91.7–97.9%

97.6%

95 CI 94.2–99.1%

97.1%

95 CI 93.5–98.8%

100%

95 CI 97.7–100%

Negatives = 208

n = 199

n = 203

n = 202

n = 208

Sensitivity^a

43.3%

95 CI: 33.7%-52.8%

89%

95 CI: 83.5%- 95.3%

29%

95 CI: 20.1%-37.6%

45%

95 CI: 35.6%- 54.8%

Specificity^a

95.7%

95CI 92.9–98.4%

98%

95 CI 95.5–99.7%

97%

95CI 94.8–99.4%

100%

100%

Agreement Cohen’s Kappa^a

0.443

0.338–0.547

0.883

0.827–0.939

0.310

0.208–0.412

0.524

0.425–0.622