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Table 3 Sensitivity and specificity of Pvr47 and COX1 targets to detect P. vivax

From: Multicopy targets for Plasmodium vivax and Plasmodium falciparum detection by colorimetric LAMP

  Mini spin column Boil & Spin
Pvr47-LAMP PvCOX1-LAMP Pvr47-LAMP PvCOX1-LAMP
P. vivax infection detected by microscopy & PCR 71.4% 95 CI 47.7–87.8% 100.00% 95 CI 80.8–100% 52.4% 95 CI 30.3–73.6% 81.0% 95 CI 57.42–93.71%
n = 21 n = 15 n = 21 n = 11 n = 17
P. vivax submicroscopic infection detected only by PCR 36.1% 95 CI 26.1–47.5% 86.8% 95 CI 77.1–92.9% 22.9% 95 CI 14.7–33.7% 36.1% 95 CI 26.1%–47.5%
n = 83 n = 30 n = 72 n = 19 n = 30
Non P. vivax infection detected by microscopy & PCR 95.7% 95 CI 91.7–97.9% 97.6% 95 CI 94.2–99.1% 97.1% 95 CI 93.5–98.8% 100% 95 CI 97.7–100%
Negatives = 208 n = 199 n = 203 n = 202 n = 208
Sensitivitya 43.3% 95 CI: 33.7%-52.8% 89% 95 CI: 83.5%- 95.3% 29% 95 CI: 20.1%-37.6% 45% 95 CI: 35.6%- 54.8%
Specificitya 95.7% 95CI 92.9–98.4% 98% 95 CI 95.5–99.7% 97% 95CI 94.8–99.4% 100% 100%
Agreement Cohen’s Kappaa 0.443 0.338–0.547 0.883 0.827–0.939 0.310 0.208–0.412 0.524 0.425–0.622
  1. aReference method: real-time PCR described by Mangold et al. [40]