Table 4 Sensitivity and specificity of Pfr364 and EMP1 targets to detect Plasmodium falciparum

P. falciparum infection detected by microscopy & PCR

100.0%

95 CI 56.1–100%

100.0%

95 CI 56.1–100%

100.0%

95 CI 56.1–100%

100.0%

95 CI 56.1–100%

n = 7

n = 7

n = 7

n = 7

n = 7

P. falciparum submicroscopic infection detected only by PCR

50.0%

95 CI 29.0–71%

72.2%

95 CI 46.4–89.3%

33.3%

95 CI 14.4–58.9%

22.2%

95 CI 7.4–48.1%

n = 18

n = 9

n = 13

n = 6

n = 4

Non P. falciparum infection detected by microscopy & PCR

99.7%

95 CI 97.8–100%

99.0%

95 CI 96.8–99.7%

99.7%

95 CI 97.8–100%

99.7%

95 CI 97.8–100%

n = 287

n = 286

n = 284

n = 286

n = 286

Sensitivity^a

64.0%

95 CI 45.2–82.8%

80.0%

95 CI 64.3–95.7%

52.0%

95 CI 32.4–71.6%

44.0%

95 CI 24.5–63.5%

Specificity^a

99.7%

95CI 99–100%

99.0%

95 CI 97.8–100%

99.7%

95CI99–100%

99.7%

95CI 99–100%

Agreement Cohen’s Kappa^a

0.745

0.595–0.896

0.820

0.698–0.941

0.646

0.470–0.823

0.572

0.381–0.764