Table 3 Model-predicted metabolic enzymes that vary substantially over time

Bicarbonate buffer system

Bicarbonate transport (\({\text{C}}{\text{l}}^{-}\text{/HC}{\text{O}}_{3}^{-}\) exchange)

0.45

0.53

0.65

0.27

0.81

Carbonic anhydrase

0.45

0.53

0.65

0.27

0.81

Glutamate metabolism

Glutathione oxidoreductase

0.91

1.06

1.30

0.53

1.61

Glycolysis

Enolase

1.19

0.53

0.87

0.60

1.57

Glyceraldehyde-3-phosphate dehydrogenase

1.19

0.53

0.87

0.60

1.57

Glucose transport (uniport)

0.46

0.28

0.55

0.27

0.87

l-Lactate reversible transport via proton symport

1.19

0.53

0.87

0.60

1.57

l-Lactate dehydrogenase

1.19

0.53

0.87

0.60

1.57

Phosphoglycerate kinase

1.19

0.53

0.87

0.60

1.57

Phosphoglycerate mutase

1.19

0.53

0.87

0.60

1.57

Pyruvate kinase

1.19

0.53

0.87

0.60

1.57

Hexokinase (d-glucose:ATP)

0.46

0.28

0.55

0.27

0.87

Triose-phosphate isomerase

0.73

0.25

0.35

0.27

0.68

Ion transport

K⁺-Cl^– cotransport

0.45

0.53

0.65

0.27

0.81

H⁺ exchange

0.36

0.13

0.71

0.27

1.41

Na⁺/K⁺ ATPase

0.92

0.25

0.45

0.25

0.85

Oxidative phosphorylation

Inorganic diphosphatase

0.29

0.15

0.32

0.14

0.30

Pentose phosphate pathway

Glucose 6-phosphate dehydrogenase

0.46

0.53

0.65

0.27

0.81

Phosphogluconate dehydrogenase

0.46

0.53

0.65

0.27

0.81

6-Phosphogluconolactonase

0.46

0.53

0.65

0.27

0.81

Ribulose 5-phosphate 3-epimerase

0.31

0.35

0.42

0.20

0.56