Table 1 Baseline characteristics of patients admitted to the AQUAMAT trial
Variable | N (%) | Artesunate N (%) | Quinine N (%) |
|---|---|---|---|
Sample size: 5425 | Â | Â | Â |
Patient demographics | Â | Â | Â |
 Congo | 422 (7.8) | 212 (50.2) | 210 (49.8) |
 Gambia | 502 (9.3) | 250 (49.8) | 252 (50.2) |
 Ghana | 436 (8) | 218 (50) | 218 (50) |
 Kenya | 442 (8.3) | 219 (49.6) | 223 (50.5) |
 Mozambique | 664 (12.2) | 332 (50) | 332 (50) |
 Nigeria | 450 (8.3) | 226 (50.2) | 224 (49.8) |
 Rwanda | 386 (7.1) | 194 (50.3) | 192 (49.7) |
 Tanzania | 1461 (26.9) | 729 (49.9) | 732 (50.1) |
 Uganda | 663 (12.2) | 333 (50.2) | 330 (49.8) |
Age (Median, IQR: 25–75) | 2 (1- 4) | 2 (1–4) | 2 (1−4) |
Females | 2611 (48.1) | 1298 (47.7) | 1316 (48.5) |
Male | 2815 (51.9) | 1418 (52.3) | 1397 (51.5) |
Clinical characteristics | Â | Â | Â |
 Coma at admission (BCS <  = 2) | 1823 (33.6) | 881 (48.3) | 942 (51.7) |
 Severe prostration (Not able to breast feed < 6 m or able to sit > 6 m) | 2974 (54.8) | 1505 (50.6) | 1469 (49.3) |
 Convulsions (> 30 min) | 1355 (31.2) | 637 (47) | 718 (52.9) |
 Decompensated shock (BP < 70mmhg) | 178 (3.3) | 88 (49.4) | 90 (50.6) |
 Deep breathing | 938 (17.3) | 495 (52.8) | 443(47.2) |
 Respiratory distress (costal in drawing/ recession / respiratory insufficiency | 867 (15.9) | 439 (50.6) | 428 (49.4) |
 Symptomatic severe anaemia (severe pallor combined with respiratory distress) | 2213 (40.8) | 1131 (51.1) | 1082 (48.9) |
 Black water fever (haemoglobinuria) | 237 (4.4) | 121 (51.1) | 116 (48.9) |
 Severe jaundice | 114 (2.1) | 55 (48.3) | 59 (51.8) |
 Anuria / Oliguria (in adults and children—History) | 7 (0.1) | 6 (85.7) | 1 (14.3) |
 Hypoglycaemia (MB-Stix < 3 mmol/L or clinical improvement after iv glucose) | 557 (10.3) | 278 (49.9) | 279 (50.1) |
 Hb g/dl: Mean: 6.5, IQR (4.8–8.8) | 6.5 (4.6–8.8) | 6.8 (4.6–8.8) |  |
 BUN mg/dl: Mean 13, IQR: 9–20) | 13 ( 9−21) | 13 (9 –20) |  |
 Base excess: Mean − 8.78, IQR:—13 to − 4) | – 7 (−13 to − 4) | – 8 (−8 to − 4) |  |