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Table 1 Baseline characteristics of patients admitted to the AQUAMAT trial

From: Identifying prognostic factors of severe metabolic acidosis and uraemia in African children with severe falciparum malaria: a secondary analysis of a randomized trial

Variable N (%) Artesunate N (%) Quinine N (%)
Sample size: 5425    
Patient demographics    
 Congo 422 (7.8) 212 (50.2) 210 (49.8)
 Gambia 502 (9.3) 250 (49.8) 252 (50.2)
 Ghana 436 (8) 218 (50) 218 (50)
 Kenya 442 (8.3) 219 (49.6) 223 (50.5)
 Mozambique 664 (12.2) 332 (50) 332 (50)
 Nigeria 450 (8.3) 226 (50.2) 224 (49.8)
 Rwanda 386 (7.1) 194 (50.3) 192 (49.7)
 Tanzania 1461 (26.9) 729 (49.9) 732 (50.1)
 Uganda 663 (12.2) 333 (50.2) 330 (49.8)
Age (Median, IQR: 25–75) 2 (1- 4) 2 (1–4) 2 (1−4)
Females 2611 (48.1) 1298 (47.7) 1316 (48.5)
Male 2815 (51.9) 1418 (52.3) 1397 (51.5)
Clinical characteristics    
 Coma at admission (BCS <  = 2) 1823 (33.6) 881 (48.3) 942 (51.7)
 Severe prostration (Not able to breast feed < 6 m or able to sit > 6 m) 2974 (54.8) 1505 (50.6) 1469 (49.3)
 Convulsions (> 30 min) 1355 (31.2) 637 (47) 718 (52.9)
 Decompensated shock (BP < 70mmhg) 178 (3.3) 88 (49.4) 90 (50.6)
 Deep breathing 938 (17.3) 495 (52.8) 443(47.2)
 Respiratory distress (costal in drawing/ recession / respiratory insufficiency 867 (15.9) 439 (50.6) 428 (49.4)
 Symptomatic severe anaemia (severe pallor combined with respiratory distress) 2213 (40.8) 1131 (51.1) 1082 (48.9)
 Black water fever (haemoglobinuria) 237 (4.4) 121 (51.1) 116 (48.9)
 Severe jaundice 114 (2.1) 55 (48.3) 59 (51.8)
 Anuria / Oliguria (in adults and children—History) 7 (0.1) 6 (85.7) 1 (14.3)
 Hypoglycaemia (MB-Stix < 3 mmol/L or clinical improvement after iv glucose) 557 (10.3) 278 (49.9) 279 (50.1)
 Hb g/dl: Mean: 6.5, IQR (4.8–8.8) 6.5 (4.6–8.8) 6.8 (4.6–8.8)  
 BUN mg/dl: Mean 13, IQR: 9–20) 13 ( 9−21) 13 (9 –20)  
 Base excess: Mean − 8.78, IQR:—13 to − 4) – 7 (−13 to − 4) – 8 (−8 to − 4)