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Table 2 In vitro growth selection coefficients for co-cultured PfMDR1 variants

From: Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum

Haplotype combination N PfMDR1 N86 PfMDR1 Y184
s Pr(>|t|) s Pr(>|t|)
NY vs. YY 5 − 0.02 0.39
NF vs. YF 3 − 0.12 < 0.0001
NF vs. YY 3 − 0.09 < 0.0001 0.09 0.008
NY vs. YF 4 − 0.04 0.07 − 0.04 0.06
NY vs. NF 4 0.13 < 0.0001
YY vs. YF 3 − 0.03 0.17
  1. The haplotypes shown indicate the N86Y and Y184F sequences. The per-generation selection coefficient (s) was derived from the relative fitness index (ω’) as per the relationship s = ω’ – 1, such that s < 0 and s > 0 indicate inferior and superior growth of the wild-type allele, respectively. s was considered to differ significantly from 0 when Pr(>|t|) was ≤ 0.05. N, number of independent growth competition assays analysed