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Table 2 In vitro growth selection coefficients for co-cultured PfMDR1 variants

From: Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum

Haplotype combination

N

PfMDR1 N86

PfMDR1 Y184

s

Pr(>|t|)

s

Pr(>|t|)

NY vs. YY

5

− 0.02

0.39

–

–

NF vs. YF

3

− 0.12

< 0.0001

–

–

NF vs. YY

3

− 0.09

< 0.0001

0.09

0.008

NY vs. YF

4

− 0.04

0.07

− 0.04

0.06

NY vs. NF

4

–

–

0.13

< 0.0001

YY vs. YF

3

–

–

− 0.03

0.17

  1. The haplotypes shown indicate the N86Y and Y184F sequences. The per-generation selection coefficient (s) was derived from the relative fitness index (ω’) as per the relationship s = ω’ – 1, such that s < 0 and s > 0 indicate inferior and superior growth of the wild-type allele, respectively. s was considered to differ significantly from 0 when Pr(>|t|) was ≤ 0.05. N, number of independent growth competition assays analysed
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Malaria Journal

ISSN: 1475-2875

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