Table 2 Associations for the risk of severe malaria
Polymorphisms | Variants | Number of studies included | Total cases/controls | Genetic model | Effect size, OR (95%CI) | Model |
|---|---|---|---|---|---|---|
TLR 9 | T1486C | 5 | 1380/2378 | Allele | 1.26 (1.08–1.48) | F |
|  |  |  | 660/1189 | Dominant | 1.29 (0.84–1.98) | R |
|  |  |  | 660/1189 | Recessive | 1.27 (0.9–1.79) | F |
|  |  |  | 325/697 | Homozygous | 1.55 (1.08–2.28) | F |
|  |  |  | 585/1091 | Heterozygous | 1.26 (0.73–2.16) | R |
TLR 9 | T1237C | 6 | 1606/2720 | Allele | 1.01 (0.81–1.27) | R |
|  |  |  | 803/1350 | Dominant | 1.32 (0.86–2.03) | R |
|  |  |  | 803/1350 | Recessive | 0.71 (0.36–1.42) | R |
|  |  |  | 442/854 | Homozygous | 0.87 (0.45–1.7) | R |
|  |  |  | 722/1145 | Heterozygous | 1.57 (0.86–2.86) | R |
TLR 4 | T399I | 2 | 202/152 | Allele | 1.03 (0.47–2.28) | F |
|  |  |  | 104/79 | Dominant | 1.05 (0.43–2.8) | F |
|  |  |  | 104/79 | Recessive | 0.73 (0.1–5.31) | F |
|  |  |  | 85/57 | Homozygous | 0.74 (0.1–5.41) | F |
|  |  |  | 102/77 | Heterozygous | 1.11 (0.43–2.91) | F |
TLR 4 | D299G | 7 | 1463/2936 | Allele | 1.16 (0.93–1.44) | F |
|  |  |  | 773/1495 | Dominant | 1.1 (0.87–1.4) | F |
|  |  |  | 773/1495 | Recessive | 0.99 (0.78–1.26) | F |
|  |  |  | 625/1207 | Homozygous | 1.29 (0.65–2.55) | F |
|  |  |  | 759/1478 | Heterozygous | 1.08 (0.84–1.37) | F |