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Table 3 Associations for the risk of susceptibility to malaria

From: Toll-like receptor 9 and 4 gene polymorphisms in susceptibility and severity of malaria: a meta-analysis of genetic association studies

Polymorphisms Variants Number of studies included Cases/controls Genetic model Effect size, OR (95% CI) Model
TLR 9 T1486C 5 3472/2610 Allele 1.03 (0.91–1.16) F
    1740/1166 Dominant 1.07 (0.78–1.47) F
    1740/1166 Recessive 0.93 (0.68–1.27) F
    801/533 Homozygous 0.85 (0.5–1.43) R
    1566/1018 Heterozygous 1.17 (0.78–1.78) R
TLR 9 T1237C 5 2867/2217 Allele 0.97 (0.84–1.12) F
    1735/1387 Dominant 0.87 (0.52–1.45) R
    1735/1387 Recessive 1.53 (0.86–2.75) R
    1225/859 Homozygous 1.28 (0.97–1.68) R
    1537/1173 Heterozygous 0.82(0.49–1.4) R
TLR 4 T399I 4 1716/1400 Allele 0.95 (0.69–1.31) F
    861/707 Dominant 0.99 (0.71–1.39) F
    861/707 Recessive 1.03 (0.73–1.46) F
    776/634 Homozygous 0.54 (0.17–1.69) F
    826/700 Heterozygous 1.13 (0.8–1.6) F
TLR 4 D299G 7 3776/2847 Allele 1.05 (0.86–1.29) F
    1959/1576 Dominant 1.11 (0.9–1.36) F
    684/1356 Recessive 0.83 (0.66–1.05) F
    545/1092 Homozygous 0.95 (0.51–1.79) F
    672/1341 Heterozygous 1.08 (0.87–1.34) F
  1. F fixed effect model, R random effects model