Table 3 Associations for the risk of susceptibility to malaria
Polymorphisms | Variants | Number of studies included | Cases/controls | Genetic model | Effect size, OR (95% CI) | Model |
|---|---|---|---|---|---|---|
TLR 9 | T1486C | 5 | 3472/2610 | Allele | 1.03 (0.91–1.16) | F |
|  |  |  | 1740/1166 | Dominant | 1.07 (0.78–1.47) | F |
|  |  |  | 1740/1166 | Recessive | 0.93 (0.68–1.27) | F |
|  |  |  | 801/533 | Homozygous | 0.85 (0.5–1.43) | R |
|  |  |  | 1566/1018 | Heterozygous | 1.17 (0.78–1.78) | R |
TLR 9 | T1237C | 5 | 2867/2217 | Allele | 0.97 (0.84–1.12) | F |
|  |  |  | 1735/1387 | Dominant | 0.87 (0.52–1.45) | R |
|  |  |  | 1735/1387 | Recessive | 1.53 (0.86–2.75) | R |
|  |  |  | 1225/859 | Homozygous | 1.28 (0.97–1.68) | R |
|  |  |  | 1537/1173 | Heterozygous | 0.82(0.49–1.4) | R |
TLR 4 | T399I | 4 | 1716/1400 | Allele | 0.95 (0.69–1.31) | F |
|  |  |  | 861/707 | Dominant | 0.99 (0.71–1.39) | F |
|  |  |  | 861/707 | Recessive | 1.03 (0.73–1.46) | F |
|  |  |  | 776/634 | Homozygous | 0.54 (0.17–1.69) | F |
|  |  |  | 826/700 | Heterozygous | 1.13 (0.8–1.6) | F |
TLR 4 | D299G | 7 | 3776/2847 | Allele | 1.05 (0.86–1.29) | F |
|  |  |  | 1959/1576 | Dominant | 1.11 (0.9–1.36) | F |
|  |  |  | 684/1356 | Recessive | 0.83 (0.66–1.05) | F |
|  |  |  | 545/1092 | Homozygous | 0.95 (0.51–1.79) | F |
|  |  |  | 672/1341 | Heterozygous | 1.08 (0.87–1.34) | F |