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Table 4 The average change coefficient (C) of the estimated haplotype frequencies with simulated population and sample haplotype frequencies for haplotype frequency > 5% across statistical methods and four conditions of LoDSNP (30%, 20%, 10%, 0%) and LoDMOI (15%, 10%, 5%, 0%)

From: Markov chain Monte Carlo Gibbs sampler approach for estimating haplotype frequencies among multiple malaria infected human blood samples

  MHF R-EM Bayesian EM MCMC Gibbs
Population haplotype (LoDSNP/LoDMOI)       
 0/0 20.8 25.2 18.7 13.2 17.7 16.1
 0.10/0.05 19.3 22.3 18.0 12.4 13.4 13.7
 0.20/0.10 19.8 19.7 18.6 13.0 11.9 12.9
 0.30/0.15 22.0 17.8 20.1 14.6 14.4 14.4
Sample haplotype (LoDSNP/LoDMOI)       
 0/0 18.8 23.7 17.4 12.0 17.2 15.4
 0.10/0.05 17.0 20.5 16.3 10.9 12.4 12.5
 0.20/0.10 17.7 17.5 17.1 11.4 10.4 11.3
 0.30/0.15 20.6 15.4 18.8 13.0 13.1 12.8
  1. Lower value represents higher accuracy
  2. MHF MalHaploFreq, R-EM malaria em, Bayesian Bayesian statistic, EM EM algorithm, MCMC Markov chain Monte Carlo, Gibbs Gibbs sampler, LoD limit of detection, SNP single nucleotide polymorphisms, MOI multiplicity of infection