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Table 2 Druggability analyses of shortlisted 15 cytoplasmic proteins of P. falciparum 3D7 essential and human host non-homolog proteins

From: Analysing the essential proteins set of Plasmodium falciparum PF3D7 for novel drug targets identification against malaria

Uniprot accession numbers PDB homolog ID’s Protein names ERRAT quality factor Ramachandran plot (residues in favored region %) QMEAN > -4 Pock drug score > 0.5 (Residues in pocket) Molecular weight (Dalton) Node degree (K) ≥ 5 (STRING analysis)
O97259_PLAF7 3fga.1.C Serine/threonine-protein phosphatase 99.3103 94.75% − 2.11 0.24 (15) 35,765.00 7.45
C0H4F3_PLAF7* 5cfi.1.A Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] 96.1832 97.20% - 0.37 0.98 (8) 17,750.19 6.36
Q8I3A9_PLAF7 4nc6.1.A GTPase-activating protein, putative 90.2778 90.71% − 3.37 0.99 (20) 50,301.05 4.36
Q8I2N2_PLAF7* 4lac.1.C Serine/threonine-protein phosphatase 93.5484 97.54% − 0.72 0.91 (14) 36,386.98 6.18
Q8I082_PLAF7 1ryt.1.A Rifin 69.7368 93.41% − 2.95 0.32 (10) 40,648.33 3.82
Q8IIU3_PLAF7 2c9o.1.A RuvB-like helicase 88.7505 92.14% − 2.41   53,405.94 7.45
Q8I599_PLAF7* 2ibj.1.A Cytochrome b5, putative 94.5205 95.00% − 0.14 1 (19) 18,244.08 6.55
Q8IDG3_PLAF7 6muw.1.C Proteasome subunit alpha type 92.2727 93.72% − 1.63   27,947.73 10
Q8IM27_PLAF7* 2a22.2.A Vacuolar protein sorting-associated protein 29 92.3977 95.63% 0.23 0.96 (16) 21,774.02 5.09
Q8IM19_PLAF7* 6k0x.1.B Multifunctional methyltransferase subunit TRM112, putative 92.233 91.80% − 1.87 1 (10) 14,234.31 8.18
Q8ILZ5_PLAF7 6y4l.1.A ER membrane protein complex subunit 2 100 95.92% − 2.03 0.97 (16) 34,952.82 4.36
C6S3I2_PLAF7 6t69.1.A MORN repeat-containing protein 5 68.3333 87.14% − 0.84 0.98 (12) 17,938.95 1.33
Q8IKK5_PLAF7 1w98.1.B Mediator of RNA polymerase II transcription subunit 20, putative 88.6179 93.80% − 3.17 0.99 (11) 36,709.76  
Q8IKC5_PLAF7 4l02.1.A Diacylglycerol kinase 85.8025 81.58% − 8.09 0.98 (32) 57,642.42 7.09
Q8ID85_PLAF7* 4ww4.1.B RuvB-like helicase 91.3242 94.46% − 1.49 1 (14) 54,629.36 7.27
  1. The steric* indicates shortlisted 06 best druggable targets