Table 2 Druggability analyses of shortlisted 15 cytoplasmic proteins of P. falciparum 3D7 essential and human host non-homolog proteins
Uniprot accession numbers | PDB homolog ID’s | Protein names | ERRAT quality factor | Ramachandran plot (residues in favored region %) | QMEAN > -4 | Pock drug score > 0.5 (Residues in pocket) | Molecular weight (Dalton) | Node degree (K) ≥ 5 (STRING analysis) |
|---|---|---|---|---|---|---|---|---|
O97259_PLAF7 | 3fga.1.C | Serine/threonine-protein phosphatase | 99.3103 | 94.75% | − 2.11 | 0.24 (15) | 35,765.00 | 7.45 |
C0H4F3_PLAF7* | 5cfi.1.A | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] | 96.1832 | 97.20% | - 0.37 | 0.98 (8) | 17,750.19 | 6.36 |
Q8I3A9_PLAF7 | 4nc6.1.A | GTPase-activating protein, putative | 90.2778 | 90.71% | − 3.37 | 0.99 (20) | 50,301.05 | 4.36 |
Q8I2N2_PLAF7* | 4lac.1.C | Serine/threonine-protein phosphatase | 93.5484 | 97.54% | − 0.72 | 0.91 (14) | 36,386.98 | 6.18 |
Q8I082_PLAF7 | 1ryt.1.A | Rifin | 69.7368 | 93.41% | − 2.95 | 0.32 (10) | 40,648.33 | 3.82 |
Q8IIU3_PLAF7 | 2c9o.1.A | RuvB-like helicase | 88.7505 | 92.14% | − 2.41 |  | 53,405.94 | 7.45 |
Q8I599_PLAF7* | 2ibj.1.A | Cytochrome b5, putative | 94.5205 | 95.00% | − 0.14 | 1 (19) | 18,244.08 | 6.55 |
Q8IDG3_PLAF7 | 6muw.1.C | Proteasome subunit alpha type | 92.2727 | 93.72% | − 1.63 |  | 27,947.73 | 10 |
Q8IM27_PLAF7* | 2a22.2.A | Vacuolar protein sorting-associated protein 29 | 92.3977 | 95.63% | 0.23 | 0.96 (16) | 21,774.02 | 5.09 |
Q8IM19_PLAF7* | 6k0x.1.B | Multifunctional methyltransferase subunit TRM112, putative | 92.233 | 91.80% | − 1.87 | 1 (10) | 14,234.31 | 8.18 |
Q8ILZ5_PLAF7 | 6y4l.1.A | ER membrane protein complex subunit 2 | 100 | 95.92% | − 2.03 | 0.97 (16) | 34,952.82 | 4.36 |
C6S3I2_PLAF7 | 6t69.1.A | MORN repeat-containing protein 5 | 68.3333 | 87.14% | − 0.84 | 0.98 (12) | 17,938.95 | 1.33 |
Q8IKK5_PLAF7 | 1w98.1.B | Mediator of RNA polymerase II transcription subunit 20, putative | 88.6179 | 93.80% | − 3.17 | 0.99 (11) | 36,709.76 |  |
Q8IKC5_PLAF7 | 4l02.1.A | Diacylglycerol kinase | 85.8025 | 81.58% | − 8.09 | 0.98 (32) | 57,642.42 | 7.09 |
Q8ID85_PLAF7* | 4ww4.1.B | RuvB-like helicase | 91.3242 | 94.46% | − 1.49 | 1 (14) | 54,629.36 | 7.27 |