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Table 3 The potential yield of reactive case detection using RDTs in study villages at the time of baseline surveys M0 (see also Fig. 5 illustrating the yield of reactive case detection in the GMS)

From: Clustering of malaria in households in the Greater Mekong Subregion: operational implications for reactive case detection

  Alla Pf Pv P. spp.b
(a) Households with a RDT positive household member (#members) 169 (773) 124 (564) 71 (368) NA
(b1) Households with a Plasmodium infected member which density reported which had > 1 HH member residing in the HH (#all members) 135 (669) 80 (401) 58 (325) 34 (213)
(b2) Households with a Plasmodium infected member which density reported which had > 1 household member residing in the household (#member excluded 1 index case from each household) 135 (534) 80 (321) 58 (267) 34 (179)
 2 to 3 household members residing in the household (#all member) 37 (96) 21 (54) 13 (35) 4 (11)
 4 to 5 household members residing in the household (#all member) 59 (269) 34 (155) 23 (105) 15 (64)
 ≥ 6 household members residing in the household (#all member) 39 (304) 25 (192) 22 (185) 15 (138)
(c) Households with a second case PCR detectable Plasmodium infection (#non-index asymptomatic cases) 6 (10) 2 (4) 4 (4) NA
(d) Households with second case RDT detectable Plasmodium infection (#non-index asymptomatic cases) 3 (5) 1 (3) 2 (2) NA
(e) Yield PCR; n/N, % (95% CI) 10/534, 1.9% (0.9 to 3.4) 4/534, 0.7% (0.2 to 1.9%) 4/534, 0.7% (0.2 to 1.9%) NA
(f) Yield RDT; n/N, % (95% CI) 5/534, 0.9% (0.3 to 2.2) 3/534, 0.6% (0.1 to 1.6%) 2/534, 0.4% (0.05 to 1.6%)  
  1. The yield was estimated through the following steps: (a) the number of households with a member who had a positive RDT which could trigger a reactive case detection investigation. (b) Among those households in (a) the number of households with one or more additional members. (c) Of those households the number of households with Plasmodium infections of sufficient parasite density to be detectable by DBS-PCR (parasite density > 5000/mL) or by RDTs (parasite density > 50,000/mL) was estimated. The yield was then calculated as DBS-PCR detectable cases and RDT respectively minus index cases divided by the number household members minus index cases detected in (b). The number of househfold members are indicated in brackets (n)
  2. Pf P. falciparum or mixed infection, Pv P. vivax or mixed infection, NA not applicable
  3. aIncluded Plasmodium spp.
  4. bThis column was defined using uPCR only
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Malaria Journal

ISSN: 1475-2875

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