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Table 1 Summary table of studies examining the effect of malaria treatment during pregnancy on low birth weight infants

From: The impact of malaria during pregnancy on low birth weight in East-Africa: a topical review

Authors Country Study design (year) Sample size Treatment; frequency Method for determining malaria infection Results/comment
Braun et al. [11] Western Uganda Cross-sectional study (2013) 915 IPTp, SP;
Start in 2nd trimester, then with every ANC visit
Polymerase chain reaction of parasite DNA P. falciparuma infection was significantly associated with LBWb
IPTpc—> no significant influence on the presence of P. falciparum infection
Mbonye et al. [12] Mukono district, Uganda Non-randomized community trial (2003–2005) 2785 IPTp, SP;
One dose in 2nd and one in 3rd trimester
Self-reported (based on fever, headache, joint pain, general weakness) Lower prevalence of LBW (6%) with the new delivery system vs. with health units (p < 0.03)
Mikomangwa et al. [13] Dar-es-Salaam, Tanzania Facility-based observational cross-sectional study (2018) 631 IPTp, SP;
Start in 2nd trimester, then with every ANC visit
Rapid antigen-based test The prevalence of LBW was 6.5%. Malaria positive women had 11 times increased risk of LBW compared to those who were negative (p = 0.04)
 ≥ 3 doses of IPTp-SPd—> 83% decreased risk of LBW compared to those who did not use IPTp-SP (p = 0.05)
Mosha et al. [14] Moshi and Rufiji, Tanzania Prospective observational study (2012) 350 IPTp;
Start in 2nd trimester, then monthly
Polymerase chain reaction of parasite DNA No significant association between IPTp use and reduced risk of LBW
Ndeserua et al. [15] Rufiji, Tanzania Cross-sectional study (2012) 350 2 doses SP; One dose in 2nd and one in 3rd trimester Quantification of parasites in blood smear Two doses SP during pregnancy was insignificantly associated with risk of LBW (p = 0.73)
Ndyomugyenyi et al. [16] Kabale, Uganda Randomized controlled trial (2004–2007) 5775 ITNe + placebo
or
ITN + IPTp
or
IPTp;
Start in 2nd trimester, then with every ANC visit
Quantification of parasites in blood smear There was no significant difference between the three intervention groups in the prevalence of LBW (p = 0.802)
Van Eijk et al. [17] Kenya Cohort study (1999–2000) 889 IPTp, SP;
Start in 2nd trimester, then with every ANC visit
Quantification of parasites in blood smear 1 dose IPTp—> associated with a mean increased BWf of 54 g (p = 0.11)
 ≥ 2 doses IPTp- > associated with a mean increased BW of 128 g (p = 0.004) compared with mothers who had not used IPTp
  1. aPlasmodium falciparum, bLow birth weight, cIntermittent preventive treatment during pregnancy, dIntermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine, eInsecticide-treated nets, fBirth weight. Note, all papers used the WHO definition of LBW (birth weight < 2.5 kg)