Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children

Table 5 Logistic regression analysis of malaria specific (anti-AMA1) IgG subclasses levels among the different study groups

Dependent Variable	Model of independent variables		OR (95% CI)	P value
IgG1 AMA1	Uncomplicated malaria	MFC^a	1.04 (1.01 to1.07)	0.012
IgG1 AMA1	Uncomplicated malaria	SM^b	0.89 (0.84 to 0.94)	< 0.001
IgG2 AMA1	Uncomplicated malaria	MFC	1.02 (0.95 to 1.08)	0.640
IgG2 AMA1	Uncomplicated malaria	SM	1.41 (1.27 to 1.57)	< 0.001
IgG3 AMA1	Uncomplicated malaria	MFC	1.70 (1.47 to 1.95)	< 0.001
IgG3 AMA1	Uncomplicated malaria	SM	0.52 (0.43 to 0.62)	< 0.001
IgG4 AMA1	Uncomplicated malaria	MFC	1.08 (0.65 to 1.79)	0.77
IgG4 AMA1	Uncomplicated malaria	SM	15.57 (8.3 to 29.20)	< 0.001

^aOR represent odds ratios while CI represents confidence intervals. In model (A) uncomplicated versus malaria-free control “MFC”: malaria-free controls were assigned 0 uncomplicated malaria patients were assigned 1 in the logistic regression analysis. OR above 1 represented value higher levels antimalarial IgG subclass associated to uncomplicated malaria while less than 1 value represented malaria-free controls
^bIn model (B) severe malaria versus uncomplicated malaria: uncomplicated malaria was assigned 0 severe malaria patients were assigned 1 in the logistic regression analysis. OR above 1 represented value higher levels antimalarial IgG subclass associated to severe malaria while less than 1 value represented uncomplicated malaria

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