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Table 5 Logistic regression analysis of malaria specific (anti-AMA1) IgG subclasses levels among the different study groups

From: Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children

Dependent Variable Model of independent variables OR (95% CI) P value
IgG1 AMA1 Uncomplicated malaria MFCa 1.04 (1.01 to1.07) 0.012
SMb 0.89 (0.84 to 0.94) < 0.001
IgG2 AMA1 Uncomplicated malaria MFC 1.02 (0.95 to 1.08) 0.640
SM 1.41 (1.27 to 1.57) < 0.001
IgG3 AMA1 Uncomplicated malaria MFC 1.70 (1.47 to 1.95) < 0.001
SM 0.52 (0.43 to 0.62) < 0.001
IgG4 AMA1 Uncomplicated malaria MFC 1.08 (0.65 to 1.79) 0.77
SM 15.57 (8.3 to 29.20) < 0.001
  1. aOR represent odds ratios while CI represents confidence intervals. In model (A) uncomplicated versus malaria-free control “MFC”: malaria-free controls were assigned 0 uncomplicated malaria patients were assigned 1 in the logistic regression analysis. OR above 1 represented value higher levels antimalarial IgG subclass associated to uncomplicated malaria while less than 1 value represented malaria-free controls
  2. bIn model (B) severe malaria versus uncomplicated malaria: uncomplicated malaria was assigned 0 severe malaria patients were assigned 1 in the logistic regression analysis. OR above 1 represented value higher levels antimalarial IgG subclass associated to severe malaria while less than 1 value represented uncomplicated malaria