Fig. 3

available at that time during infection. b Average haemoglobin concentration for each animal during the indicated time period after infection. Light gray bars indicate mean of the shown datapoints. c Platelet concentration kinetics in relation to parasitaemia before and after infection. Each dot represents the mean for all animals where data was available at that time during infection. d Average reticulocyte concentration in peripheral blood for each animal during the indicated time period after infection. Light gray bars indicate mean of the shown datapoints. e Relationship of haemoglobin and reticulocyte concentration kinetics with reticulocyte production index during infection. Each dot represents the mean for all animals where data were available at that time during infection. f Representative flow cytometry plots showing the relative quantification of erythroid progenitors present in bone marrow aspirates collected before and during infection. Percentages in blue indicate the percentage of each population in the gate out of the erythroid compartment defined as SscloCD41a-CD45-LiveDead. Gating strategy can be found in Additional file 13: Fig. S4. g Relative quantification of erythroid progenitors as in f. h Representative H&E-stained bone marrow samples from uninfected, malaria and P. knowlesi infected kra monkeys at the indicated time points. i Quantification of erythropoietin by ELISA in the plasma of a subset of kra monkeys after infections with P. knowlesi. j Quantification of processes resulting in the elimination of RBCs using a recursive mathematical model. Statistical significance was assessed using a linear mixed-effect model followed by a Tukey–Kramer HSD post-hoc analysis. p-values of < 0.05 were considered statistically significant. Error bars = SEM. Asterisks indicate statistical significance