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Table 2 Results from Cox proportional hazard model analyses of time to parasite density less than 1000 per µl, adjusting for baseline parasite density, year and anti-malarial administered

From: Plasmodium falciparum clearance time in Malawian children with cerebral malaria: a retrospective cohort study

  Year Number of subjects Hazard ratio
(95% CI) *
Hours to parasite reduction to < 1000 parasites/µl
median (95% CI)
All quinine years 2010–2013    30 (30,30)
Individual years 2010 118 0.34 (0.24, 0.48) 30 (30,36)
2011 68 0.46 (0.32, 0.68) 30 (24,30)
2012 38 0.29 (0.18, 0.47) 24 (18,36)
2013 35 0.57 (0.36, 0.90) 24 (18,30)
All artesunate years 2014–2019    18 (12,18)
Individual years 2014 53 1.00 18 (18,24)
2015 30 1.36 (0.86, 2.17) 18 (12,24)
2016 30 1.20 (0.76, 1.90) 12 (12,18)
2017 45 1.25 (0.82, 1.89) 18 (12,24)
2018 29 0.85 (0.53, 1.36) 18 (12,24)
2019 19 0.95 (0.55, 1.63) 15 (12,36)
  1. *All hazard ratio estimates are relative to reference year 2014, the first year of artesunate use in Malawi