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Table 1 The area under the curve of the estimated probability distribution

From: Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy: an individual participant data meta-analysis

Day AL in Africaa 95% CI] AL in Asiaa [95% CI] DP in Africa (PIP mg/kg ≤ 48) [95% CI] DP in Africa (PIP mg/kg > 48) [95% CI]
28 0.42 [0.26–0.53] 0.68 [0.55–0.85] 0.39 [0.25–0.52] 0.20 [0.00–0.36]
35 0.63 [0.40–0.78] 0.88 [0.78–0.99] 0.69 [0.53–0.83] 0.36 [0.03–0.59]
42 0.79 [0.53–0.97] 0.98 [0.93–1.00] 0.91 [0.78–1.00] 0.53 [0.10–0.81]
49 0.91 [0.64–1.00] 1.00 [0.93–1.00] 1.00 [0.93–1.00] 0.70 [0.22–0.99]
56 0.97 [0.74–1.00] 1.00 [0.94–1.00] 1.00 [0.98–1.00] 0.84 [0.36–1.00]
63 1.00 [0.81–1.00] 1.00 1.00 0.93 [0.47–1.00]
  1. AL, artemether-lumefantrine; DP, dihydroartemisinin-piperaquine; PIP, piperaquine; CI, confidence interval
  2. aEstimated in children < 5 years in Africa and in patients of all ages from Asia
  3. The 95% confidence interval was estimated from 1000 bootstrap samples of data for AL; for DP not under-dosed this was from 925 samples, and for DP under-dosed this was based on 987 bootstrap samples drawn from the original dataset