Prediction of the CYP2D6 enzymatic activity based on investigating of the CYP2D6 genotypes around the vivax malaria patients in Yunnan Province, China

Table 3 Prediction of CYP2D6 enzyme activity based on genotyping of CDS chain of vivax malaria patients in Yunnan Province

Genotypes	No (CR)^a	Genotype mothed		PROVEAN mothed			Different type of cases
Genotypes	No (CR)^a	Value	Classify	Score	Cutoff	Function	No. SR (TPR)^b	No. NR (TPR)^b	P
1/1	43 (13.4)	2.0	NM	2.000	− 2.5	NT	2 (3.2)	41 (16.0)	0.008^c
2/2	10 (3.1)	2.0	NM	− 0.887	− 2.5	NT	4 (6.3)	6 (2.3)	0.216
1/2	22 (6.9)	2.0	NM	− 0.773	− 2.5	NT	7 (11.1)	15 (5.8)	0.228
2/10	32 (10.0)	1.25	NM	− 1.568	− 2.5	NT	2 (3.2)	30 (11.7)	0.044^c
1/10	58 (18.1)	1.25	NM	− 2.341	− 2.5	NT	6 (9.5)	52 (20.2)	0.048 ^c
10/10	86 (26.9)	0.50	IM	− 1.671	− 2.5	NT	18 (28.6)	68 (26.5)	0.735
10/39	9 (2.8)	0.75	IM	− 2.666	− 2.5	DT	6 (9.5)	3 (1.2)	0.002^c
39/39	3 (0.9)	1.0	IM	1.350	− 2.5	NT	2 (3.2)	1 (0.4)	0.100
2/39	5 (1.6)	1.50	NM	− 1.098	− 2.5	NT	3 (4.8)	2 (0.8)	0.054
4/4	1 (0.3)	0	PM	− 9.431	− 2.5	DT	1 (1.6)	0 (0.0)	0.197
Others ^d	51 (15.9)	–	–	–	–	–	12 (19.0)	39 (15.2)	0.452
Total	320						63	257

^aCR is acronym for constituent ratio
^bTPR is acronym for Test positive rate
^cChi-square test (significant level at P < 0.05)
^dThe diploids with at least one undocumented allele (*m, *n, *o, *p, *q,*r, *s,*t, *u, *v, *w and *x)

ISSN: 1475-2875