Table 3 An. gambiae s.l. target site allele frequencies from three study sites in East DRC
Resistance mutation | Study site (Province) | # Mosquitoes testeda | Homozygote mutation (RR) | Heterozygote mutation (RS) | Homozygote wild type (SS) | Allele frequency | χ2 test | p-value | ||
|---|---|---|---|---|---|---|---|---|---|---|
R | S | |||||||||
N1575Y | Tchonka (Sud-Kivu) | 129 | 0 | 0 | 129 | 0 | 1.0 | – | – | |
Tushunguti (Sud-Kivu) | 32 | 0 | 0 | 32 | 0 | 1.0 | – | – | ||
Kibali (Haut-Uélé) | 29 | 0 | 0 | 29 | 0 | 1.0 | – | – | ||
L43F-CYP4J5 | Tchonka (Sud-Kivu) | 126 | 5 | 95 | 26 | 0.42 | 0.58 | 38.26 | < 0.0001 | |
Tushunguti (Sud-Kivu) | 32 | 1 | 31 | 0 | 0.52 | 0.48 | 28.24 | < 0.0001 | ||
Kibali (Haut-Uélé) | 28 | 0 | 24 | 4 | 0.43 | 0.57 | 15.75 | < 0.0001 | ||
G119S-ace1 | Tchonka (Sud-Kivu) | 131 | 1 | 41 | 89 | 0.16 | 0.84 | 2.59 | 0.11 | |
Tushunguti (Sud-Kivu) | 32 | 0 | 12 | 20 | 0.19 | 0.81 | 1.70 | 0.19 | ||
Kibali (Haut-Uélé) | 28 | 1 | 4 | 23 | 0.11 | 0.89 | 1.80 | 0.18 | ||