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Table 3 Logistic regression analyses of factors related to early and late parasitological failures (no. of observations = 7482)

From: Dynamic changes in genetic diversity, drug resistance mutations, and treatment outcomes of falciparum malaria from the low-transmission to the pre-elimination phase on the islands of São Tomé and Príncipe

Variable Coefficient SE z value p-value OR (95% CI)
Early parasitological failure
(day 3 positive)
Age − 0.028 0.004 − 6.752  < 0.001 0.97 (0.960.98)
Male − 0.048 0.093 − 0.513 0.608 0.95 (0.801.14)
Urban 0.015 0.254 0.059 0.953 1.02 (0.621.67)
Period B vs. D 1.761 0.199 8.860  < 0.001 5.82 (3.948.59)
Period C vs. D 1.003 0.199 5.046  < 0.001 2.73 (1.854.03)
Endemic season 0.026 0.093 0.278 0.781 1.03 (0.861.23)
Log10 parasite density at day 0* 0.368 0.058 6.379  < 0.001 1.44 (1.291.62)
Quinine* 0.672 0.150 4.490  < 0.001 1.96 (1.462.63)
Late parasitological failure
(days 7–28 positive)
Age − 0.022 0.005 − 4.775  < 0.001 0.98 (0.970.99)
Male − 0.173 0.112 − 1.542 0.123 0.84 (0.671.05)
Urban − 0.239 0.296 − 0.807 0.419 0.79 (0.941.22)
Period B vs. D 0.647 0.189 3.419  < 0.001 1.91 (1.322.77)
Period C vs. D 0.487 0.181 2.691 0.007 1.63 (1.142.32)
Endemic season − 0.089 0.113 − 0.788 0.430 0.91 (0.731.14)
Log10 parasite density at day 0* 0.069 0.064 1.071 0.284 1.07 (0.941.22)
Quinine* 0.648 0.162 3.997  < 0.001 1.91 (1.392.63)
  1. The definition of each variable is described in the method section. Period B and C are the low transmission periods with ascending and descending trend, respectively. Period D is the pre-elimination phase. The asterisk denotes that the mediation analysis was performed to examine the relationship between “parasite density → treatment → early/late parasitological failures” in Additional file 1: Fig. S6. Significant p-values (p < 0.05) are shown in italic