The presence of circulating antibody secreting cells and long-lived memory B cell responses to reticulocyte binding protein 1a in Plasmodium vivax patients

Table 1 Characteristics of study participants assessed for PvRBP1a antigenicity during acute and recovery phases of vivax malaria

Characteristic	Acute P. vivax patients					Recovered P. vivax subjects				Healthy subjects
	Total IgG				IgG subclasses	Kinetic responses
	All	HR	LR	NR	IgG subclasses	3m	9m	12m
Number	68	11	30	27	41 (of total 68)	16 (of total 68)				43
Age mean ± SD	32.42 ± 14.43	46.56 ± 11.78	31.24 ± 13.25	27.77 ± 13.26	32.42 ± 14.43	47.86 ± 14.14				27.22 ± 6.85
Gender
Male	45	7	20	18	27	12	12	12		20
Female	23	4	10	9	14	4	4	4		23
Nationality
Thai	49	8	25	16	33	15	15	15		43
Myanmar	19	3	5	11	8	1	1	1		0
No. of prior infection
0	68	11	30	27	41	16	15	15		0
1	0	0	0	0	0	0	1	1		0
> 1	0	0	0	0	0	0	0	0		0
No. of recorded re-infections	0	0	0	0	0	0	0	0		0
Parasitaemia (parasite/µL) mean ± SD (range)	5318.81 ± 4213.53 (120–15,000)					0	0		0	0

HR high responders, indicates high response to PvRBP1a; LR low responders, indicates low response to PvRBP1a; NR non-responders, indicates negative response PvRBP1a; 3m, 9m and 12m times since recovery from Plasmodium vivax infection, 3, 9 and 12 months

ISSN: 1475-2875