In vivo efficacy of anti-malarial drugs against clinical Plasmodium vivax malaria in Ethiopia: a systematic review and meta-analysis

Table 3 Parasite and fever clearance reported from individual studies included in the anti-malarial drug efficacy study, 1 January, 2000 to 31 March, 2021

Study ID	Patients enrolled	Patients who completed follow-up	Patients with ACPR	Parasite clearance (%)^a			Fever clearance (%)^a
Study ID	Patients enrolled	Patients who completed follow-up	Patients with ACPR	D2	D3	D7	D1	D2	D3	D7
Abreha et al. [30]
CQ	104	96 (d28)/	92 (d28)/	95.2	98.1	100	89.5	100	100	100
CQ	104	94 (d42)	77 (d42)	95.2	98.1	100	89.5	100	100	100
CQ & PQ	100	94 (d28)/	94 (d28)/	95	100	100	100	100	100	100
CQ & PQ	100	89 (d42)	89 (d42)	95	100	100	100	100	100	100
AL	102	92 (d28)/	81 (d28)/	91.2	100	100	97.6	100	100	100
AL	102	90 (d42)	62 (d42)	91.2	100	100	97.6	100	100	100
AL & PQ	92	90 (d28)/	84 (d28)/	100	100	100	97.4	97.4	97.4	100
AL & PQ	92	89 (d42)	77 (d42)	100	100	100	97.4	97.4	97.4	100
Assefa et al. [26]	63	60	58	ND	ND	ND	ND	ND	ND	ND
Beyene et al. [24]	76	69	67	83	83	100	94.2	95.5	100	100
Getachew et al. [38]	288	236	229	93.8	100	100	ND	98.8	100	100
Hwang et al. [25]
· CQ	120	108 (d28)/ 107 (d42)	98 (d28)/ 73 (d42)	94	98.1	100	44.1	77.8	90.4	100
AL	122	114 (d28)/ 113 (d42)	86 (d28), 66 (d42)	100	100	100	37.7	74.3	89.3	100
Kanche et al. [39]^b	81	74	74	98.8	100	100	ND	93.8	100	100
Ketema et al. [31]^b	84	78	78	88	88	100	65.4	70.5	89.7	91.7
Ketema et al. [23]^b	87	80	69	95.4	95.4	95.4	ND	ND	ND	ND
Teka et al. [22]	87	83	79	ND	98	100	ND	ND	ND	ND
Seifu et al. [40]	87	76	71	91.3	100	100	ND	27.6	ND	ND
Shumbej et al. [27]	87	81	81	100	100	100	ND	100	100	100
Yeshanew et al. [41]	128	115	115	ND	75.6	100	ND	ND	71.7	100
Yeshiwondim et al. [28]
CQ	145	141	141	80.1	97.9	100	59.6	97.2	100	100
CQ & PQ	145	136	136	72.6	99.3	100	94.9	98.5	100	100
Yohannes et al. [29]
CQ	63	51	51	ND	ND	ND	90.1	100	100	100
AL	96	81	81	ND	ND	ND	89.8	100	100	100

ND No data available, d28 day 28, d42 day 42
^aParasite/fever clearance rates were taken from reports of individual studies
^bWhen parasite or fever clearance only was reported, the rate was calculated by subtracting the percentage with parasites or fever from 100%

ISSN: 1475-2875