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Fig. 4 | Malaria Journal

Fig. 4

From: How radical is radical cure? Site-specific biases in clinical trials underestimate the effect of radical cure on Plasmodium vivax hypnozoites

Fig. 4

Effect of rate of relapse and duration of follow-up on efficacy estimates. A LM-detectable recurrence-free efficacy estimated from simulated clinical trials is shown at different EIRs, mean times to relapse, and durations of follow-up. Each point is the median of 200 simulations, and each bar is the interquartile range. The color represents the mean time to relapse (30, 60, 90, or 180 days), and each vertical strip for each EIR is the duration of follow-up (90, 180, 365, or 730 days). The dotted line is the clearance probability simulated in each trial. B The percentage of trial participants expected to relapse as a function of the duration of follow-up is shown for different mean times to relapse. C The percentage of trial participants expected to be re-infected as a function of the duration of follow-up is shown for different EIRs

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Malaria Journal

ISSN: 1475-2875

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