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Fig. 1 | Malaria Journal

Fig. 1

From: Functional characterization of 5′ UTR cis-acting sequence elements that modulate translational efficiency in Plasmodium falciparum and humans

Fig. 1

Comparison of features within the 5′ UTRs of genes in the bottom 10% (n = 209) and top 10% (n = 209) of TEs in the late trophozoite stage using data from Caro et al. [18]. a A histogram of the log2(TE)s of genes expressed in the late trophozoite stage included in subsequent analysis. The vertical dotted lines indicate the bottom 10% (yellow) and top 10% (blue) of 5′ UTRs. b The number of uAUGs normalized to the length of the 5′ UTRs in the bottom 10% (yellow) and top 10% (blue) of TEs in the late trophozoite stage. The two distributions are statistically distinct, KS test-statistic 0.47, p-value 1.4*10−21. c The average number of uAUGs in the 5′ UTRs within a 130-nucleotide window sliding by 5 nucleotides up to 1000 nucleotides of the bottom 10% (yellow) and top 10% blue. d The distribution of GC content in the bottom 10% (yellow) and top 10% (blue) of TEs in the late trophozoite stage are statistically distinct, KS test statistic comparison of the two: 0.23 p-value 2.24*10−5. e The average GC content within a 130-nucleotides sliding window moving 5 nucleotides up to 1000 nucleotides from the translation start site. Bottom 10% (yellow) and top 10% blue

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