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Table 2 Proportions of each component and experimental conditions in scale-up preparation of F5 and F8 liposomes

From: Decoquinate liposomes: highly effective clearance of Plasmodium parasites causing severe malaria

Large scale F5 liposomes F8 liposomes
Ingredients
 DQ (mg) 200 400
 SPC (mg) 800 800
 P188 (mg) 1600
 PEG400 (mg) 6500
 HS15 (mg) 1300
 EtOH (ml) 150 300
 H2O (ml) 2850 2400
Total volume (ml) 3000 3000
Stirring time post mixing (min) 5 5
Stirring speed (rpm) 1000 1000
  1. DQ decoquinate, SPC soy phosphatidylcholine, P188 poloxamer 188, PEG400 polyethylene glycol 400, HS15 macrogol 15 hydroxystearate, EtOH anhydrous ethanol, TFF tangential flow filtration