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Table 2 Proportions of each component and experimental conditions in scale-up preparation of F5 and F8 liposomes

From: Decoquinate liposomes: highly effective clearance of Plasmodium parasites causing severe malaria

Large scale

F5 liposomes

F8 liposomes

Ingredients

 DQ (mg)

200

400

 SPC (mg)

800

800

 P188 (mg)

1600

–

 PEG400 (mg)

6500

–

 HS15 (mg)

–

1300

 EtOH (ml)

150

300

 H2O (ml)

2850

2400

Total volume (ml)

3000

3000

Stirring time post mixing (min)

5

5

Stirring speed (rpm)

1000

1000

  1. DQ decoquinate, SPC soy phosphatidylcholine, P188 poloxamer 188, PEG400 polyethylene glycol 400, HS15 macrogol 15 hydroxystearate, EtOH anhydrous ethanol, TFF tangential flow filtration