Fig. 1
From: Apoptotic changes and aquaporin-1 expression in the choroid plexus of cerebral malaria patients
Histopathology, caspase-3, and aquaporin-1 expressions of CPECs in the normal control (NC), non-cerebral malaria (NCM), and cerebral malaria (CM) groups. In A, the normal CP displays a central structure of capillaries, which is overlaid by a single layer of CPECs attached to the basement membrane. The CP from the NCM group shows shrinkage of CPECs and detachment of a few CPECs. Marked nuclear condensation, CPEC shrinkage (inset, arrows), and detachment of CPECs from the basement membrane are noted in the CM group. B illustrates caspase-3 expression in CPECs. The NCM and CM groups display enhanced nuclear expression of caspase-3, which is significantly increased in the CM group. C demonstrates aquaporin (AQP)-1 expression in CPECs. The NC group shows high expression of AQP-1 in CPECs. A marked decreased in AQP-1 expression was noted in the CM group. (Images in (A): 200 × magnification; images in (B) and (C): 400 × magnification)