Table 3 Incidence of hospitalized and clinically diagnosed malnutrition in study children by study group overall and by study year (mITT population)
Outcomes | PYAR | Events | Rate per 1000 PYAR (95% CI) | Hazard ratio (95% CI) RTS,S alone or combined groups vs. SMC alone | Hazard ratio (95% CI) Combined vs. RTS,S alone |
|---|---|---|---|---|---|
Hospitalization for primary diagnosis of malnutrition | |||||
SMC alone | 5449.9 | 2 | 0.367 (0.092, 1.47) | Reference | |
RTS,S alone | 5535.7 | 3 | 0.542 (0.175, 1.68) | 1.48 (0.25, 8.80) | Reference |
Combined | 5508.0 | 5 | 0.908 (0.378, 2.18) | 2.48 (0.48, 12.8) | 1.68 (0.40, 6.94) |
Hospitalization for malnutrition-related conditions | |||||
SMC alone | 5449.9 | 5 | 0.92 (0.38, 2.20) | Reference | |
RTS,S alone | 5535.7 | 6 | 1.08 (0.49, 2.41) | 1.20 (0.37, 3.91) | Reference |
Combined | 5508.0 | 7 | 1.27 (0.61, 2.67) | 1.40 (0.44, 4.39) | 1.16 (0.39, 3.44) |
Clinically diagnosed malnutrition | |||||
SMC alone | 5449.9 | 49 | 8.99 (6.80, 11.9) | Reference | |
RTS,S alone | 5535.7 | 58 | 10.5 (8.10, 13.6) | 1.14 (0.65, 1.99) | Reference |
Combined | 5508.0 | 41 | 7.44 (5.48, 10.1) | 0.82 (0.49, 1.40) | 0.73 (0.40, 1.30) |
Year 1 | |||||
SMC alone | 1794.3 | 39 | 21.7 (15.9, 29.7) | Reference | |
RTS,S alone | 1816.8 | 33 | 18.2 (12.9, 25.5) | 0.81 (0.45, 1.46) | Reference |
Combined | 1802.3 | 29 | 16.1 (11.2, 23.2) | 0.73 (0.41, 1.33) | 0.90 (0.47, 1.72) |
Year 2 | |||||
SMC alone | 1868.5 | 9 | 4.82 (2.51, 9.26) | Reference | |
RTS,S alone | 1903.4 | 19 | 9.98 (6.37, 15.6) | 2.03 (0.77, 5.31) | Reference |
Combined | 1894.4 | 9 | 4.75 (2.47, 9.13) | 0.98 (0.37, 2.59) | 0.48 (0.19, 1.21) |
Year 3 | |||||
SMC alone | 1787.1 | 1 | 0.560 (0.079, 3.97) | Reference | |
RTS,S alone | 1815.5 | 6 | 3.30 (1.48, 7.36) | 5.73 (0.66, 50.0) | Reference |
Combined | 1811.3 | 3 | 1.66 (0.534, 5.14) | 2.94 (0.31, 28.2) | 0.51 (0.12, 2.21) |