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Table 4 Comparison of TBS, uRDT and cRDT sensitivity stratified by parasite density (p/µL) as determined by qPCR

From: Diagnostic performance and comparison of ultrasensitive and conventional rapid diagnostic test, thick blood smear and quantitative PCR for detection of low-density Plasmodium falciparum infections during a controlled human malaria infection study in Equatorial Guinea

Group density (p/µL)

# samples qPCR (+) (reference)

TBS (+)

TBS sensitivity (95% CI)

uRDT

uRDT sensitivity (95% CI)

cRDT

cRDT sensitivity (95% CI)

< 1

37

0

–

0

–

0

–

1–10

38

1

3% (0–14)

1

3% (0–14)

1

3% (0–14)

11–50

25

7

28% (12–49)

4

16% (5–36)

0

–

51–100

7

2

29% (4–71)

5

71% (29–96)

2

29% (4–71)

> 100

16

14

88% (62–98)

11

69% (41–89)

7

44% (20–70)

  1. Number of samples and sensitivity of TBS, uRDT and cRDT stratified by parasite density (p/µL). All cases were low parasite density samples that occurred during CHMI follow-up and were 100% specific compared to qPCR