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Table 1 Molecular genotyping of pfexo-modified, parental and clinical P. falciparum parasites

From: A single point mutation in the Plasmodium falciparum 3′–5′ exonuclease does not alter piperaquine susceptibility

Sample

PfK13

C580Y

PfEXO

E415G

PfCRT

Copy number variation

pfpm2/3 break point

T93S

H97Y

F145I

I218F

M343L

C350R

G353V

pfpm1

pfpm2

pfpm3

3D7

C

E

T

H

F

I

M

C

G

1.00

1.00

1.00

1

B5

C

E

T

H

F

I

M

C

G

1.37

0.93

1.99

1

B5-rexo-E415G-B8

C

G

T

H

F

I

M

C

G

1.19

0.74

2.08

1

ASAP-21

Y

G

T

H

I

I

M

C

G

1.25

2.31

2.60

> 1

ASAP-168

Y

G

T

H

F

I

M

C

G

1.18

1.11

1.88

> 1

  1. Underline and bold letters indicate either mutations or multiple copy number. A cut-off copy number of 1.6 is used to define pfpm2 and pfpm3 multiple copy number
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Malaria Journal

ISSN: 1475-2875

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