Malaria Journal

Table 2 PfHRP2_RDT performance compared to PCR and microscopy examination in asymptomatic (N = 266) and symptomatic (N = 196) infections

From: Low prevalence of Plasmodium falciparum parasites lacking pfhrp2/3 genes among asymptomatic and symptomatic school-age children in Kinshasa, Democratic Republic of Congo

PfHRP2_RDTs	Asymptomatic infections
	Pfldh_qPCR			Microscopy
	Positive	Negative	Total	Positive	Negative	Total
Positive	150	24	174	119	55	174
Negative	37	55	92	11	81	92
Total	187	79	266	130	136	266
Se (%) (CI 95%)	80 (74, 86)			92 (85, 96)
Sp (%) (CI 95%)	70 (58, 80)			60 (51, 68)
PPV (%) (CI 95%)	86 (81, 90)			84 (81, 87)
NPV (%) (CI 95%)	60 (52, 68)			75 (63, 84)
Kappa*	0.48, p < 0.001			0.51, p < 0.001

PfHRP2_RDTs	Symptomatic infections
	Pfldh_qPCR			Microscopy
	Positive	Negative	Total	Positive	Negative	Total
Positive	128	3	131	114	17	131
Negative	43	22	65	8	57	65
Total	171	25	196	122	74	196
Se (%) (CI 95%)	75 (68, 81)			93 (88, 97)
Sp (%) (CI 95%)	88 (69, 98)			77 (66, 86)
PPV (%) (CI 95%)	98 (94, 99)			97 (95, 98)
NPV (%) (CI 95%)	34 (28, 41)			64 (47, 78)
Kappa*	0.37, p < 0.001			0.72, p < 0.001

Se sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, CI confidence interval
*Statistical analysis using Cohen’s kappa coefficient test, significance at p < 0.05

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ISSN: 1475-2875

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