Table 3 Demographics, laboratory investigations, imaging, and outcomes for the cohort (n = 174)
Variable | Value |
|---|---|
Demographics | |
Age (months), mean (SD) | 58 (± 32) |
Male, n (%) | 97 (56) |
Vital signs | |
Temperature (°C), median [IQR] | 38.3 [37.4,39.1] |
Heart rate (beats/min), median [IQR] | 140 [126,157] |
RR (breaths/min), median [IQR] | 34 [29, 42] |
Oxygen saturation (%), median [IQR] | 97 [96,98] |
MBP (mmHg), median [IQR] | 77 [71,86] |
Hemodynamic findings | |
Pulse pressure (mmHg), median [IQR] | 40 [35, 45] |
Stroke volume index (ml/m2), median [IQR] | 38 [32, 44] |
Cardiac index (l/min/m2), median [IQR] | 5 [4.3,5.8] |
Systemic vascular resistive index (d.s.cm−5m2), median [IQR] | 1314 [1152,1630] |
Laboratory investigations | |
Packed Cell Volume (%), median [IQR] | 26 [22, 30] |
Glucose (mmol/L), median [IQR] | 5.65 [4.5, 6.5] |
Lactate (mmol/L), median [IQR] | 4.2 [2.3,6.9] |
Parasites/microliter blood, median [IQR] | 255,000 [9300,665000] |
PfHRP2 (ng/mL), median [IQR] | 571 [219,1332] |
pH, median [IQR] | 7.41 [7.35,7.46] |
CO2 (mmHg), median [IQR] | 28 [24, 33] |
Base excess, median [IQR] | − 5 [− 9,− 2] |
Sodium (mEq/L), median [IQR] | 138 [135,143] |
Bicarbonate (mmol/L), median [IQR] | 17 [13, 20] |
Clinical Features | |
Retinopathy positive, n (%) | 115 (66%) |
Blantyre coma score, n (%) | |
0 | 26 (15%) |
1 | 64 (37%) |
2 | 84 (48%) |
Seizures on EEG, n (%) | 16 (9%) |
Papilloedema present, n (%) | 10 (7%) |
Opening pressure (cm H20), median [IQR] | 17 [12, 22] |
ONSD (mm), median [IQR] | 4.8 [4.4,5.1] |
Time to coma resolution (hrs), median [IQR] | 38 [22,70] |
Magnetic resonance imaging findings (n = 94)ǂ | |
Brain volume score, n (%) | |
3 | 7 (7%) |
4 | 8 (8%) |
5 | 33 (35%) |
6 | 24 (26%) |
7 | 18 (19%) |
8 | 4 (5%) |
Outcome | |
Good, n (%) | |
PCPC 1–2 (normal, mild disability) | 118 (68%) |
Poor, n (%) | |
PCPC 3–5 (moderate to severe disability) | 33 (19%) |
PCPC 6 (died) | 23 (13%) |