Fig. 1

Analysis of Plasmodium spp. Cox11 amino acid sequences. The P. falciparum Cox11 amino acid sequence was aligned with Cox11 from A Theileria, Babesia, Trypanosoma, Arabidopsis, Saccharomyces, Homo and Mus sequences and B Plasmodium reichenowi, Plasmodium berghei, Plasmodium chabaudi, Plasmodium yoelii, Plasmodium vivax, and Plasmodium knowlesi. Key: a: P. falciparum Cox11 transmembrane domain, b: conserved cysteine (P. falciparum C60) and c: conserved CFCF motif (P. falciparum C155 and C157). The cloned P. falciparum sequence is in bold script. C for comparative purposes the protein model for Sinorhizobium meliloti Cox11 (PDB:ISO9) amino acid sequence served as a template (left panel) for homology modelling of the P. falciparum Cox11 amino acid sequence (right panel) and the two models superimposed (middle panel). The S. meliloti and P. falciparum Cox11 Cys-100/102 and 155/157 positions in the conserved CFCF sequence are illustrated