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Table 2 Integral gene drive system parameters

From: Population replacement gene drive characteristics for malaria elimination in a range of seasonal transmission settings: a modelling study

Parameter Description Default value Range
d1 Drive efficiency and transmission rate (applies to both driver and effector target loci) 1 0.9–1
p_nhej Probability of NHEJ if drive transmission fails 0.5
p_ihdr Probability of incomplete HDR during homing 1E−4
p_r_nhej Probability of resistance arising from NHEJ 1/3
p_r_ihdr Probability of resistance arising from incomplete HDR 1/3
1—p_r_nhej Probability of loss of gene function from NHEJ 2/3
1—p_r_ihdr Probability of loss gene function from incomplete HDR 2/3
sd1 Fitness cost of hijacking driver target locus 0
sd2 Fitness cost of hijacking effector target locus 0
sn Fitness cost of driver expression 0.05
se2 Fitness cost of effector expression 0 0–0.5
sm Fitness cost of loss of gene function 1
hd1 Dominance coefficient for hijacking at driver target locus 0.5
hd2 Dominance coefficient for hijacking at effector target locus 0.5
hn Dominance coefficient for driver expression 0.5
he2 Dominance coefficient for effector expression 0.5
hm Dominance coefficient for loss of gene function 0.2
hrc1 Dominance coefficient for parasite refractoriness 1
rc Homozygous degree of parasite refractoriness 1 0.5–1
rr10 Initial population driver target site resistance frequency 0
rr20 Initial population effector target site resistance frequency 0 0–0.1
  1. All genetic parameters used in integral gene drive mosquito release simulations. Default values are representative of and consistent with other published works [31, 37, 54]. Default values for tested parameters (d1, se2, rc, rr20) are used on accompanying website visualizations