Table 2 Integral gene drive system parameters

d1

Drive efficiency and transmission rate (applies to both driver and effector target loci)

1

0.9–1

p_nhej

Probability of NHEJ if drive transmission fails

0.5

–

p_ihdr

Probability of incomplete HDR during homing

1E−4

–

p_r_nhej

Probability of resistance arising from NHEJ

1/3

–

p_r_ihdr

Probability of resistance arising from incomplete HDR

1/3

–

1—p_r_nhej

Probability of loss of gene function from NHEJ

2/3

–

1—p_r_ihdr

Probability of loss gene function from incomplete HDR

2/3

–

sd1

Fitness cost of hijacking driver target locus

0

–

sd2

Fitness cost of hijacking effector target locus

0

–

sn

Fitness cost of driver expression

0.05

–

se2

Fitness cost of effector expression

0

0–0.5

sm

Fitness cost of loss of gene function

1

–

hd1

Dominance coefficient for hijacking at driver target locus

0.5

–

hd2

Dominance coefficient for hijacking at effector target locus

0.5

–

hn

Dominance coefficient for driver expression

0.5

–

he2

Dominance coefficient for effector expression

0.5

–

hm

Dominance coefficient for loss of gene function

0.2

–

hrc1

Dominance coefficient for parasite refractoriness

1

–

rc

Homozygous degree of parasite refractoriness

1

0.5–1

rr10

Initial population driver target site resistance frequency

0

–

rr20

Initial population effector target site resistance frequency

0

0–0.1