Table 2 Summary of each model aspect evaluated during the development and sensitivity phases, with performance measures
Phase | Model number | Description | TRSS | Number (%) of observations in predicted interval |
|---|---|---|---|---|
Development | Base | Previously published model, with updated \(f^{*}\) value of 33.6 | 176.2 | 27 (13%) |
1 | 40 h parasite life cycle | 185.5 | 27 (13%) | |
2 | Body fluid estimated by weight. BV = 0.07 × weight, ECF = 0.2 × weight | 171.5 | 30 (14%) | |
3 | Body fluid estimated by weight and sex. BV = 0.07 × weight, ECF = 0.245 × weight for males and ECF = 0.22 × weight for females | 164.2 | 37 (18%) | |
4 | Elimination half-life estimate of 1.67 days | 131.1 | 43 (21%) | |
5 | Elimination half-life lower bound of 95% CI of 1.11 days | 102.7 | 51 (25%) | |
6 | Elimination half-life upper bound of 95% CI of 3.40 days | 172.7 | 28 (13%) | |
7 (Final) | Body fluid estimated by weight and sex. BV = 0.07 × weight, ECF = 0.245 × weight for males and ECF = 0.22 × weight for females and elimination half-life of 1.67 | 122.6 | 57 (27%) | |
Sensitivity | 8 | Final model with the upper confidence bound of the 95% CI for \(f^{*}\), \(f = 42.18\) | 141.1 | 49 (24%) |
9 | Final model with the lower confidence bound of the 95% CI for \(f^{*}\), \(f = 24.97\) | 104.8 | 64 (31%) | |
10 | Final model with the upper confidence bound of the 95% CI for half-life, 3.40 days | 160.9 | 37 (18%) | |
11 | Final model with the lower bound of the 95% CI for half-life, 1.11 days | 97.2 | 57 (27%) |