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Table 2 in vivo anti-malarial activity of Ethiopian medicinal plants

From: Medicinal plants used in traditional treatment of malaria in Ethiopia: a review of ethnomedicine, anti-malarial and toxicity studies

Familya Plant species Part (s) used Parasitemia Inhibition with each extract and dose used for the treatment of the malaria infected mice (dose in mg/kg body weight) Antimalarial activity Strain of Plasmodium tested Safe dose to non-infected mice (mg/kg body weight) References
Acanthaceae (2) Adhatoda schimperiana Root Hydroalcoholic crude extract, 53.6% at 600 mg/kg Moderate Pb 2000 [50]
  Acanthus polystachyus Leave 80% methanol extract, 49.25% (400) Moderate Pb ANKA 2000 [51]
  Acanthus polystachyus Root 80% methanol, 51.48% (400) Moderate Pb ANKA 2000 [64]
Aloaceae (5) Aloe pirottae Latex 80% methanol extract, 47% % at 600 mg/kg Moderate Pb ANKA 2000 [65]
  Aloe citrina Leave latex Latex extract, 60.59% (400) Good Pb ANKA 5000 [66]
  Aloe weloensis leave latex Leave latex extract, 66.84% at 400 mg/kg Good Pb 2000 [67]
  Aloe percrassa Leave latex Water extract, 73.6% (400) Good Pb ANKA 5000 [68]
  Aloe megalacantha Leave Leave latex extract, 56.4% (400 mg/kg) Moderate Pb ANKA 2000 [69]
Anacardiaceae (1) Schinus molle Seed Methanol crude extract,66.91% at 400 mg/kg Good Pb 2000 [70]
Asclepiadaceae (1) Periploca linearifolia Stem bark Methanol extract, 56.98% (600 mg/kg) Moderate Pb ANKA 2000 [71]
Asphodelaceae (4) Asparagus africanus Leave Leave latex crude extract, 60.70% at 300 mg/kg Good Pb 1500 [72]
  Aloe debrana Leave Leave latex crude extract, 75.02% at 600 mg/kg Good Pb 5000 [52]
  Aloe macrocarpa Leave Leave exudate crude extract, 60% at 100 mg/kg, 67.8% at 200 mg/kg and 74.3% at 400 mg/kg Very good Pb ANKA 2000 [73]
  Aloe debrana Leave Methanol extract, 73.95% at 600 mg/kg Good Pb ANKA 3000 [53]
  Kniphofia foliosa Rhizome 80% methanol extract, 51.39% (200) and 61.52% (400) Good Pb ANKA 2000 [74]
Asteraceae (3) Echinops kebericho Root 70% ethanol, 57.29% (500 mg/kg) Moderate Pb ANKA 5000 [75]
  Vernonia adoensis Leave methanol extract, 83.36% (600) Moderate Pb ANKA 3000 [76]
  Artemisia abyssinica Aerial parts 80% methanol, 64.7 and 82.4% at 200 and 400 mg/kg Good Pb NE [77]
Balanitaceae (1) Balanites rotundifolia Leave 80% methanol, 67% (400) Moderate Pb ANKA 2000 [78]
Brassicaceae (1) Brassica nigra Seed 80% methanol extract, 50% (200) and 53.13% (400) Good Pb ANKA NE [79]
Caricaceae (1) Carica papaya Root & Fruit Petroleum ether fraction of fruit rind extract, 61.78% (400 mg/kg) Moderate Pb ANKA 2000 [80]
Combretaceae (2) Combretum molle Stem bark 80% methanolic extract, 59.7% at 400 mg/kg Moderate Pb 2000 [54]
  Terminalia brownii Bark Methanol crude extract, 60.2% at 400 mg/kg Good Pb ANKA 2000 [81]
  Combretum molle Seed Methanol crude extract, 63.5% at 250 mg/kg Moderate Pb ANKA NE [55]
Cucurbitaceae (1) Zehenria scabra Leave 80% methanolic extract 62.5% (100 mg/kg), 72.85% (200 mg/kg) and 76.01% (400 mg/kg) Very good Pb 2000 [82]
Euphorbiaceae (1) Croton macrostachyus Leave Methanol extract 91%, Chloroform fraction, 75.9% and methanol fraction, 64.2% at 600 mg/kg Good Pb ANKA 5000 [56]
  Croton macrostachyus Fruit & Root 80% methanol fruit extract, 70% (400) and 87% (600), root extract, 75% (400) and 89% (600) Moderate Pb ANKA 2000 [57]
Fabaceae (2) Calpurnia aurea Leaves hydromethanolic leave extract, 51.15% (60 mg/kg) Very good Pb LD50 > 300 [83]
  Indigofera spicata Root 80% methanol extract, 53.42% (600) Moderate Pb ANKA NE [84]
Lamiaceae (2) Clerodendrum Myricoides Leaves Methanol fraction, 77.24% and Ethyl acetate fraction 65.21% at 300 mg/kg Good Pb NE [58]
  Clerodendrum myricoides Leave Methanol crude extract, 82.5% at 600 mg/kg Good Pb ANKA 3000 [53]
  Ajuga remota Leave methanol extract, 77.34% at 100 mg/kg Very good Pb ANKA 2000 [61]
  Strychnos mitis Leave Aqueous extract, 74.86% (400 mg/kg) and 95.5% (600 mg/kg), hydroalcoholic fraction, 81.49% (400) and 93.97% (600) Moderate Pb ANKA 2000 [85]
Loganiaceae (1)        
Menispermaceae (1) Stephania abyssinica Leave 80% methanol crude extract, 45.60%, Ethyl acetate fraction, 51.44% and Chloroform fraction 55.80% at 400 mg/kg Moderate Pb ANKA NE [86]
Oleaceae (1) Olea europaea Stem bark Methanol extract, 52.40% at 400 mg/kg Moderate Pb 2000 [87]
Rosaceae (1) Hagenia abyssinica Stem bark Hydroalcoholic (80% methanol), 65.29% at 100 mg/kg Very good Pb, ANKA 2000 [88]
Rubiaceae (1) Gardenia ternifolia Stem bark Methanol crude extract, 59.25% at 600 mg/kg Moderate Pb 2000 [89]
Rutaceae (1) Fagaropsis angolensis Stem bark 80% methanol extract, 50.05% (200), 54.8% (400) and 59.7% (600) Moderate Pb ANKA 2000 [90]
Sapindaceae (1) Dodonaea angustifolia Root n-butanol fraction of methanolic root extract, 67.51% (600) Good Pb 2000 [59]
  Dodonea angustifolia Root Methanol crude extract, 84.52% at 600 mg/kg Good Pb ANKA 3000 [53]
  Dodonaea angustifolia Leave acetate soluble portion of the 80% aqueous MeOH extract, 80.28% at 150 mg/kg Very good Pb ANKA NE [60]
Solanaceae (1) Capsicum frutescens Var. Minima Fruit 80% methanolic crude fruit extract, 72.65 at 100 mg/kg Very good Pb 2000 [91]
Zygophyllaceae (1) Balanites rotundifolia Leave Methanol extract, 60.59% at 500 mg/kg Moderate Pb 5000 [92]
  1. aNumber of species studied by family in parentheses, Pb = Plasmodium berghei