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Table 2 Prophylactic Study

From: Evaluation of anti-malarial potency of new pyrazole-hydrazine coupled to Schiff base derivatives

Treatment

Dose (mg/kg)

Parasitaemia count

Day 3

Day 4

Day 5 (post inoculation)

Control

–

9.40 ± 1.23

14.40 ± 0.45#

16.37 ± 1.25#

BePINH

2.5

3.75 ± 1.08*

2.92 ± 1.64*

2.77 ± 1.65*

10

3.70 ± 0.64*

2.30 ± 2.72*

2.05 ± 0.72*

15

2.43 ± 0.86*

0.83 ± 0.92*

0.76 ± 1.11*

BePBeH

2.5

3.99 ± 0.74*

2.95 ± 0.49*

2.93 ± 1.06*

10

3.72 ± 0.64*

2.50 ± 0.52*

2.18 ± 0.77*

15

2.46 ± 0.75*

0.91 ± 1.62*

0.79 ± 1.19*

ACT

5

0.51 ± 0.26*

0.26 ± 0.42*

0.10 ± 0.66*

  1. Each value represents the mean ± S.E.M, n = 5
  2. ACT artemisinin-based combination therapy
  3. *,#p < 0.05 compared with control and Day 3, respectively (One-way ANOVA; Dunnett’s post hoc)
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Malaria Journal

ISSN: 1475-2875

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