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Table 2 Mean and standard deviation (SD) for clinical parameters of malaria patients with erythrocytic enzymopathies (p-values were determined using the Student’s t-test.)

From: Haematological profile of malaria patients with G6PD and PKLR variants (erythrocytic enzymopathies): a cross-sectional study in Thailand

Clinical parameters

G6PD Phenotypic status (n = 255, missing 1)

G6PD and PKLR mutations (n = 255, missing 1)

(n = 255)

G6PD normal

G6PD intermediate

p

G6PD deficiency

p

Wild-type

Mahidol

p

Other G6PD mutations

p

PKLRR41Q

p

Mahidol + PKLRR41Q

 

(n = 209)

(n = 17)

(n = 28)

(n = 215)

(n = 17)

(n = 10)

(n = 11)

(n = 1)

Hb

12.7 ± 2.0

13.2 ± 1.1

0.084

11.0 ± 2.5

0.003

12.7 ± 1.9

11.2 ± 2.7

0.041

10.6 ± 2.4

0.001

13.2 ± 1.8

0.353

13.1

(g/dl)

(6.4–17.0)

(11.6–15.3)

 

(6.5–15.3)

 

(6.4–17.0)

(6.5–15.2)

 

(7.8–15.3)

 

(8.2–15.3)

  

RBCs

4.9 ± 0.8

5.0 ± 0.5

0.542

4.3 ± 1.0

0.005

4.8 ± 0.8

4.0 ± 0.9

<0.001

4.6 ± 1.0

0.417

5.2 ± 0.5

0.100

4.95

(× 106/ul)

(1.3–7.1)

(4.3–5.8)

 

(2.2–6.0)

 

(1.3–7.1)

(2.2–5.3)

 

(2.7–6.0)

 

(4.5–6.3)

  

Hct

38.4 ± 5.7

40.2 ± 4.9

0.060

34.17 ± 7.1

0.006

38.4 ± 5.5

34.0 ± 7.2

0.029

33.9 ± 7.4

0.014

41.2 ± 5.3

0.094

39.9

(%)

(19.4–52.8)

(35.3–48.4)

 

(20.7–44.7)

 

(19.4–52.8)

(20.7–44.7)

 

(22.0–44.4)

 

(29.7–47.4)

  

MCV

79.3 ± 8.6

81.4 ± 6.7

0.327

81.2 ± 8.9

0.281

79.5 ± 8.4

85.8 ± 7.3

0.004

74.1 ± 6.9

0.046

79.3 ± 9.7

0.938

80.6

(fl)

(47.8–96.5)

(66.0–88.8)

 

(62.5–95.9)

 

(47.8–96.5)

(71.4–95.9)

 

(62.5–82.2)

 

(58.9–90.0)

  

MCH

26.3 ± 3.3

26.7 ± 1.7

0.404

26.2 ± 3.7

0.879

26.3 ± 3.2

28.0 ± 2.8

0.046

23.2 ± 3.3

0.002

25.5 ± 3.68

0.371

26.6

(pg/cell)

(16.2–38.5)

(23.2–29.3)

 

(17.3–30.7)

 

(16.3–38.5)

(23.1–30.7)

 

(17.3–29.1)

 

(16.2–29.3)

  

MCHC

32.8 ± 2.4

32.8 ± 1.4

0.975

31.0 ± 6.0

0.137

32.9 ± 2.4

30.7 ± 7.6

0.269

31.4 ± 2.5

0.055

32.0 ± 2.8

0.239

33.0

(g/dl)

(9.0–36.6)

(30.9–35.8)

 

(3.0–36.6)

 

(9.00–36.6)

(3.0–36.6)

 

(26.9–35.4)

 

(27.5–35.0)

  

RDW

15.2 ± 1.6

14.7 ± 0.7

0.015

14.9 ± 2.2

0.387

15.1 ± 1.5

14.4 ± 1.4

0.054

15.7 ± 3.1

0.558

15.8 ± 2.2

0.319

15.3

(%)

(12.7–23.8)

(13.4–16.2)

 

(12.3–23.8)

 

(12.7–23.8)

(12.3–17.5)

 

(12.8–23.8)

 

(13.1–19.1)

  

Reticulocyte

1.5 ± 1.1

1.1 ± 0.4

0.120

2.8 ± 2.1

0.005

1.5 ± 1.1

3.6 ± 2.4

0.008

1.9 ± 0.9

0.225

1.5 ± 1.0

0.812

1.5

(%)

(0.3–7.8)

(0.5–2.0)

 

(0.5–9.6)

 

(0.3–7.8)

(1.6–9.6)

 

(0.5–3.0)

 

(0.7–3.8)

  

Platelet

107.2 ± 82.3

73.71 ± 56.1

0.102

111.26 ± 57.8

0.803

105.6 ± 83.0

131.8 ± 60.0

0.215

83.0 ± 41.2

0.392

84.0 ± 31.2

0.390

65

(× 103/mm3)

(14.0–790.0)

(7.0–217.0)

 

(11.0–275.0)

 

(7.0–790.0)

(52.0–275.0)

 

(11.0–150.0)

 

(44.0–146.0)

  

MPV

13.3 ± 52.1

9.6 ± 3.1

0.770

9.3 ± 1.4

0.693

13.2 ± 51.3

9.5 ± 1.5

0.773

9.0 ± 1.9

0.795

8.4 ± 0.9

0.754

9.1

(fl)

(0.0–738.0)

(0.0–13.6)

 

(7.2–13.5)

 

(0.0–738.0)

(7.2–13.5)

 

(7.4–10.9)

 

(7.5–10.5)

  

TB

1.3 ± 2.0

3.3 ± 9.0

0.357

1.4 ± 0.8

0.668

1.4 ± 3.2

1.6 ± 0.9

0.875

1.3 ± 0.7

0.862

0.9 ± 0.5

0.548

0.55

(mg/dl)

(0.2–21.3)

(0.4–38.0)

 

(0.3–3.3)

 

(0.2–37.98)

(0.3–3.3)

 

(0.5–2.4)

 

(0.3–2.0)

  

DB

0.6 ± 1.6

2.3 ± 7.9

0.377

0.6 ± 0.5

0.915

0.8 ± 2.8

0.6 ± 0.6

0.863

0.5 ± 0.3

0.753

0.4 ± 0.2

0.591

0.29

(mg/dl)

(0.0–17.7)

(0.2–33.0)

 

(0.0–2.4)

 

(0.0–33.0)

(0.1–2.4)

 

(0.04–1.06)

 

(0.1–0.7)

  

IDB

0.6 ± 0.5

0.9 ± 1.3

0.305

0.8 ± 0.5

0.055

0.6 ± 0.6

0.9 ± 0.6

0.120

0.7 ± 0.4

0.617

0.5 ± 0.3

0.461

0.26

(mg/dl)

(0.1–3.6)

(0.2–5.0)

 

(0.1–2.5)

 

(0.0–5.0)

(0.1–2.5)

 

(0.3–1.67)

 

(0.2–1.3)

  

Parasitemia

27,419.2 ± 38,747.8

33,379.0 ± 59,709.0

0.691

24,841.9 ± 26,411.5

0.738

27,988.3 ± 41,225.2

25,633.9 ± 24,868.7

0.822

25,982.3 ± 30,289.8

0.879

24,681.4 ± 25,455.0

0.793

765

(parasite/ul)

(35–278,250)

(1–185,820)

 

(133–81,900)

 

(1–278,250)

(133–72,750)

 

(800–81,900)

 

(1018–69,940)

  
  1. Hb: haemoglobin; RBCs: red blood cells; Hct: haematocrit; MCV: mean corpuscular volume; MCH: mean corpuscular haemoglobin; MCHC: mean corpuscular Hb concentration; WBCs: white blood cells; RDW: red cell distribution width; TB: total bilirubin; DB: direct bilirubin; IDB: indirect bilirubin; Bold values indicate statistical significance at the p-value <0.05 level