Clinical parameters | G6PD Phenotypic status (n = 255, missing 1) | G6PD and PKLR mutations (n = 255, missing 1) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(n = 255) | G6PD normal | G6PD intermediate | p | G6PD deficiency | p | Wild-type | Mahidol | p | Other G6PD mutations | p | PKLRR41Q | p | Mahidol + PKLRR41Q |
 | (n = 209) | (n = 17) | (n = 28) | (n = 215) | (n = 17) | (n = 10) | (n = 11) | (n = 1) | |||||
Hb | 12.7 ± 2.0 | 13.2 ± 1.1 | 0.084 | 11.0 ± 2.5 | 0.003 | 12.7 ± 1.9 | 11.2 ± 2.7 | 0.041 | 10.6 ± 2.4 | 0.001 | 13.2 ± 1.8 | 0.353 | 13.1 |
(g/dl) | (6.4–17.0) | (11.6–15.3) |  | (6.5–15.3) |  | (6.4–17.0) | (6.5–15.2) |  | (7.8–15.3) |  | (8.2–15.3) |  |  |
RBCs | 4.9 ± 0.8 | 5.0 ± 0.5 | 0.542 | 4.3 ± 1.0 | 0.005 | 4.8 ± 0.8 | 4.0 ± 0.9 | <0.001 | 4.6 ± 1.0 | 0.417 | 5.2 ± 0.5 | 0.100 | 4.95 |
(× 106/ul) | (1.3–7.1) | (4.3–5.8) |  | (2.2–6.0) |  | (1.3–7.1) | (2.2–5.3) |  | (2.7–6.0) |  | (4.5–6.3) |  |  |
Hct | 38.4 ± 5.7 | 40.2 ± 4.9 | 0.060 | 34.17 ± 7.1 | 0.006 | 38.4 ± 5.5 | 34.0 ± 7.2 | 0.029 | 33.9 ± 7.4 | 0.014 | 41.2 ± 5.3 | 0.094 | 39.9 |
(%) | (19.4–52.8) | (35.3–48.4) |  | (20.7–44.7) |  | (19.4–52.8) | (20.7–44.7) |  | (22.0–44.4) |  | (29.7–47.4) |  |  |
MCV | 79.3 ± 8.6 | 81.4 ± 6.7 | 0.327 | 81.2 ± 8.9 | 0.281 | 79.5 ± 8.4 | 85.8 ± 7.3 | 0.004 | 74.1 ± 6.9 | 0.046 | 79.3 ± 9.7 | 0.938 | 80.6 |
(fl) | (47.8–96.5) | (66.0–88.8) |  | (62.5–95.9) |  | (47.8–96.5) | (71.4–95.9) |  | (62.5–82.2) |  | (58.9–90.0) |  |  |
MCH | 26.3 ± 3.3 | 26.7 ± 1.7 | 0.404 | 26.2 ± 3.7 | 0.879 | 26.3 ± 3.2 | 28.0 ± 2.8 | 0.046 | 23.2 ± 3.3 | 0.002 | 25.5 ± 3.68 | 0.371 | 26.6 |
(pg/cell) | (16.2–38.5) | (23.2–29.3) |  | (17.3–30.7) |  | (16.3–38.5) | (23.1–30.7) |  | (17.3–29.1) |  | (16.2–29.3) |  |  |
MCHC | 32.8 ± 2.4 | 32.8 ± 1.4 | 0.975 | 31.0 ± 6.0 | 0.137 | 32.9 ± 2.4 | 30.7 ± 7.6 | 0.269 | 31.4 ± 2.5 | 0.055 | 32.0 ± 2.8 | 0.239 | 33.0 |
(g/dl) | (9.0–36.6) | (30.9–35.8) |  | (3.0–36.6) |  | (9.00–36.6) | (3.0–36.6) |  | (26.9–35.4) |  | (27.5–35.0) |  |  |
RDW | 15.2 ± 1.6 | 14.7 ± 0.7 | 0.015 | 14.9 ± 2.2 | 0.387 | 15.1 ± 1.5 | 14.4 ± 1.4 | 0.054 | 15.7 ± 3.1 | 0.558 | 15.8 ± 2.2 | 0.319 | 15.3 |
(%) | (12.7–23.8) | (13.4–16.2) |  | (12.3–23.8) |  | (12.7–23.8) | (12.3–17.5) |  | (12.8–23.8) |  | (13.1–19.1) |  |  |
Reticulocyte | 1.5 ± 1.1 | 1.1 ± 0.4 | 0.120 | 2.8 ± 2.1 | 0.005 | 1.5 ± 1.1 | 3.6 ± 2.4 | 0.008 | 1.9 ± 0.9 | 0.225 | 1.5 ± 1.0 | 0.812 | 1.5 |
(%) | (0.3–7.8) | (0.5–2.0) |  | (0.5–9.6) |  | (0.3–7.8) | (1.6–9.6) |  | (0.5–3.0) |  | (0.7–3.8) |  |  |
Platelet | 107.2 ± 82.3 | 73.71 ± 56.1 | 0.102 | 111.26 ± 57.8 | 0.803 | 105.6 ± 83.0 | 131.8 ± 60.0 | 0.215 | 83.0 ± 41.2 | 0.392 | 84.0 ± 31.2 | 0.390 | 65 |
(× 103/mm3) | (14.0–790.0) | (7.0–217.0) |  | (11.0–275.0) |  | (7.0–790.0) | (52.0–275.0) |  | (11.0–150.0) |  | (44.0–146.0) |  |  |
MPV | 13.3 ± 52.1 | 9.6 ± 3.1 | 0.770 | 9.3 ± 1.4 | 0.693 | 13.2 ± 51.3 | 9.5 ± 1.5 | 0.773 | 9.0 ± 1.9 | 0.795 | 8.4 ± 0.9 | 0.754 | 9.1 |
(fl) | (0.0–738.0) | (0.0–13.6) |  | (7.2–13.5) |  | (0.0–738.0) | (7.2–13.5) |  | (7.4–10.9) |  | (7.5–10.5) |  |  |
TB | 1.3 ± 2.0 | 3.3 ± 9.0 | 0.357 | 1.4 ± 0.8 | 0.668 | 1.4 ± 3.2 | 1.6 ± 0.9 | 0.875 | 1.3 ± 0.7 | 0.862 | 0.9 ± 0.5 | 0.548 | 0.55 |
(mg/dl) | (0.2–21.3) | (0.4–38.0) |  | (0.3–3.3) |  | (0.2–37.98) | (0.3–3.3) |  | (0.5–2.4) |  | (0.3–2.0) |  |  |
DB | 0.6 ± 1.6 | 2.3 ± 7.9 | 0.377 | 0.6 ± 0.5 | 0.915 | 0.8 ± 2.8 | 0.6 ± 0.6 | 0.863 | 0.5 ± 0.3 | 0.753 | 0.4 ± 0.2 | 0.591 | 0.29 |
(mg/dl) | (0.0–17.7) | (0.2–33.0) |  | (0.0–2.4) |  | (0.0–33.0) | (0.1–2.4) |  | (0.04–1.06) |  | (0.1–0.7) |  |  |
IDB | 0.6 ± 0.5 | 0.9 ± 1.3 | 0.305 | 0.8 ± 0.5 | 0.055 | 0.6 ± 0.6 | 0.9 ± 0.6 | 0.120 | 0.7 ± 0.4 | 0.617 | 0.5 ± 0.3 | 0.461 | 0.26 |
(mg/dl) | (0.1–3.6) | (0.2–5.0) |  | (0.1–2.5) |  | (0.0–5.0) | (0.1–2.5) |  | (0.3–1.67) |  | (0.2–1.3) |  |  |
Parasitemia | 27,419.2 ± 38,747.8 | 33,379.0 ± 59,709.0 | 0.691 | 24,841.9 ± 26,411.5 | 0.738 | 27,988.3 ± 41,225.2 | 25,633.9 ± 24,868.7 | 0.822 | 25,982.3 ± 30,289.8 | 0.879 | 24,681.4 ± 25,455.0 | 0.793 | 765 |
(parasite/ul) | (35–278,250) | (1–185,820) |  | (133–81,900) |  | (1–278,250) | (133–72,750) |  | (800–81,900) |  | (1018–69,940) |  |  |