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Table 2 Mean and standard deviation (SD) for clinical parameters of malaria patients with erythrocytic enzymopathies (p-values were determined using the Student’s t-test.)

From: Haematological profile of malaria patients with G6PD and PKLR variants (erythrocytic enzymopathies): a cross-sectional study in Thailand

Clinical parameters G6PD Phenotypic status (n = 255, missing 1) G6PD and PKLR mutations (n = 255, missing 1)
(n = 255) G6PD normal G6PD intermediate p G6PD deficiency p Wild-type Mahidol p Other G6PD mutations p PKLRR41Q p Mahidol + PKLRR41Q
  (n = 209) (n = 17) (n = 28) (n = 215) (n = 17) (n = 10) (n = 11) (n = 1)
Hb 12.7 ± 2.0 13.2 ± 1.1 0.084 11.0 ± 2.5 0.003 12.7 ± 1.9 11.2 ± 2.7 0.041 10.6 ± 2.4 0.001 13.2 ± 1.8 0.353 13.1
(g/dl) (6.4–17.0) (11.6–15.3)   (6.5–15.3)   (6.4–17.0) (6.5–15.2)   (7.8–15.3)   (8.2–15.3)   
RBCs 4.9 ± 0.8 5.0 ± 0.5 0.542 4.3 ± 1.0 0.005 4.8 ± 0.8 4.0 ± 0.9 <0.001 4.6 ± 1.0 0.417 5.2 ± 0.5 0.100 4.95
(× 106/ul) (1.3–7.1) (4.3–5.8)   (2.2–6.0)   (1.3–7.1) (2.2–5.3)   (2.7–6.0)   (4.5–6.3)   
Hct 38.4 ± 5.7 40.2 ± 4.9 0.060 34.17 ± 7.1 0.006 38.4 ± 5.5 34.0 ± 7.2 0.029 33.9 ± 7.4 0.014 41.2 ± 5.3 0.094 39.9
(%) (19.4–52.8) (35.3–48.4)   (20.7–44.7)   (19.4–52.8) (20.7–44.7)   (22.0–44.4)   (29.7–47.4)   
MCV 79.3 ± 8.6 81.4 ± 6.7 0.327 81.2 ± 8.9 0.281 79.5 ± 8.4 85.8 ± 7.3 0.004 74.1 ± 6.9 0.046 79.3 ± 9.7 0.938 80.6
(fl) (47.8–96.5) (66.0–88.8)   (62.5–95.9)   (47.8–96.5) (71.4–95.9)   (62.5–82.2)   (58.9–90.0)   
MCH 26.3 ± 3.3 26.7 ± 1.7 0.404 26.2 ± 3.7 0.879 26.3 ± 3.2 28.0 ± 2.8 0.046 23.2 ± 3.3 0.002 25.5 ± 3.68 0.371 26.6
(pg/cell) (16.2–38.5) (23.2–29.3)   (17.3–30.7)   (16.3–38.5) (23.1–30.7)   (17.3–29.1)   (16.2–29.3)   
MCHC 32.8 ± 2.4 32.8 ± 1.4 0.975 31.0 ± 6.0 0.137 32.9 ± 2.4 30.7 ± 7.6 0.269 31.4 ± 2.5 0.055 32.0 ± 2.8 0.239 33.0
(g/dl) (9.0–36.6) (30.9–35.8)   (3.0–36.6)   (9.00–36.6) (3.0–36.6)   (26.9–35.4)   (27.5–35.0)   
RDW 15.2 ± 1.6 14.7 ± 0.7 0.015 14.9 ± 2.2 0.387 15.1 ± 1.5 14.4 ± 1.4 0.054 15.7 ± 3.1 0.558 15.8 ± 2.2 0.319 15.3
(%) (12.7–23.8) (13.4–16.2)   (12.3–23.8)   (12.7–23.8) (12.3–17.5)   (12.8–23.8)   (13.1–19.1)   
Reticulocyte 1.5 ± 1.1 1.1 ± 0.4 0.120 2.8 ± 2.1 0.005 1.5 ± 1.1 3.6 ± 2.4 0.008 1.9 ± 0.9 0.225 1.5 ± 1.0 0.812 1.5
(%) (0.3–7.8) (0.5–2.0)   (0.5–9.6)   (0.3–7.8) (1.6–9.6)   (0.5–3.0)   (0.7–3.8)   
Platelet 107.2 ± 82.3 73.71 ± 56.1 0.102 111.26 ± 57.8 0.803 105.6 ± 83.0 131.8 ± 60.0 0.215 83.0 ± 41.2 0.392 84.0 ± 31.2 0.390 65
(× 103/mm3) (14.0–790.0) (7.0–217.0)   (11.0–275.0)   (7.0–790.0) (52.0–275.0)   (11.0–150.0)   (44.0–146.0)   
MPV 13.3 ± 52.1 9.6 ± 3.1 0.770 9.3 ± 1.4 0.693 13.2 ± 51.3 9.5 ± 1.5 0.773 9.0 ± 1.9 0.795 8.4 ± 0.9 0.754 9.1
(fl) (0.0–738.0) (0.0–13.6)   (7.2–13.5)   (0.0–738.0) (7.2–13.5)   (7.4–10.9)   (7.5–10.5)   
TB 1.3 ± 2.0 3.3 ± 9.0 0.357 1.4 ± 0.8 0.668 1.4 ± 3.2 1.6 ± 0.9 0.875 1.3 ± 0.7 0.862 0.9 ± 0.5 0.548 0.55
(mg/dl) (0.2–21.3) (0.4–38.0)   (0.3–3.3)   (0.2–37.98) (0.3–3.3)   (0.5–2.4)   (0.3–2.0)   
DB 0.6 ± 1.6 2.3 ± 7.9 0.377 0.6 ± 0.5 0.915 0.8 ± 2.8 0.6 ± 0.6 0.863 0.5 ± 0.3 0.753 0.4 ± 0.2 0.591 0.29
(mg/dl) (0.0–17.7) (0.2–33.0)   (0.0–2.4)   (0.0–33.0) (0.1–2.4)   (0.04–1.06)   (0.1–0.7)   
IDB 0.6 ± 0.5 0.9 ± 1.3 0.305 0.8 ± 0.5 0.055 0.6 ± 0.6 0.9 ± 0.6 0.120 0.7 ± 0.4 0.617 0.5 ± 0.3 0.461 0.26
(mg/dl) (0.1–3.6) (0.2–5.0)   (0.1–2.5)   (0.0–5.0) (0.1–2.5)   (0.3–1.67)   (0.2–1.3)   
Parasitemia 27,419.2 ± 38,747.8 33,379.0 ± 59,709.0 0.691 24,841.9 ± 26,411.5 0.738 27,988.3 ± 41,225.2 25,633.9 ± 24,868.7 0.822 25,982.3 ± 30,289.8 0.879 24,681.4 ± 25,455.0 0.793 765
(parasite/ul) (35–278,250) (1–185,820)   (133–81,900)   (1–278,250) (133–72,750)   (800–81,900)   (1018–69,940)   
  1. Hb: haemoglobin; RBCs: red blood cells; Hct: haematocrit; MCV: mean corpuscular volume; MCH: mean corpuscular haemoglobin; MCHC: mean corpuscular Hb concentration; WBCs: white blood cells; RDW: red cell distribution width; TB: total bilirubin; DB: direct bilirubin; IDB: indirect bilirubin; Bold values indicate statistical significance at the p-value <0.05 level