Table 1 Prevalence of SP mutant SNPs and haplotypes between 2012 and 2017
Gene | SNP | Percent in 2012 | Percent in 2017 | P value |
|---|---|---|---|---|
Pfdhfr |  | n = 212 | n = 111 |  |
C50R | 0 | 0 | N/A | |
N51I | 100 | 100 | 1.000 | |
C59R | 97.2 | 96.4 | 0.965 | |
S108N | 100 | 100 | 1.000 | |
I164L | 0.9 | 0 | 0.779 | |
Pfdhps |  | n = 210 | n = 111 |  |
S436H | 10.5 | 34.6 | 0.001 | |
A437G | 100 | 100 | 1.000 | |
K540E | 99.5 | 97.2 | 0.221 | |
A581G | 1.0 | 0 | 0.792 | |
| Â | A613T | 0 | 0 | N/A |
Mutation number | Haplotype | Percent in 2012 | Percent in 2017 | P value |
|---|---|---|---|---|
Pfdhfr |  | n = 212 | n = 111 |  |
Wild | C50N51C59S108I164 | 0 | 0 | N/A |
Double | C50I51C59N108I164 | 2.3 | 3.6 | 0.772 |
Triple | C50I51R59N108I164 | 96.7 | 96.4 | 0.965 |
Triple | C50I51C59N108L164 | 0.5 | 0 | 1.000 |
Quadruple | C50I51R59N108L164 | 0.5 | 0 | 1.000 |
Pfdhps |  | n = 210 | n = 107 |  |
Wild | S436A437K540A581A613 | 0 | 0 | N/A |
Single | S436G437K540A581A613 | 0.5 | 2.8 | 0.221 |
Double | S436G437E540A581A613 | 88.1 | 62.6 | 0.001 |
Triple | H436G437E540A581A613 | 10.5 | 34.6 | 0.001 |
Triple | S436G437E540G581A613 | 1.0 | 0 | 0.793 |
dhfr/dhps |  | n = 209 | n = 107 |  |
Wild | C50N51C59S108I164/S436A437K540A581A613 | 0 | 0 | N/A |
Triple | C50I51C59N108I164/S436G437K540A581A613 | 0 | 1 | 1.000 |
Quadruple | C50I51C59N108I164/S436G437E540A581A613 | 2.4 | 2.8 | 1.000 |
Quadruple | C50I51R59N108I164/S436G437K540A581A613 | 0.5 | 1.9 | 0.553 |
Quintuple | C50I51R59N108I164/S436G437E540A581A613 | 85.2 | 59.8 | 0.001 |
Sextuple | C50I51R59N108I164/H436G437E540A581A613 | 10.1 | 34.6 | 0.001 |
Sextuple | C50I51C59N108L164/H436G437E540A581A613 | 0.5 | 0 | 1.000 |
Sextuple | C50I51R59N108L164/S436G437E540A581A613 | 0.5 | 0 | 1.000 |
Sextuple | C50I51R59N108I164/S436G437E540G581A613 | 1.0 | 0 | 0.791 |