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Table 4 Diagnostic performance of RDT, and microscopy in reference to PCR as gold standard

From: Significance of nested PCR testing for the detection of low-density malaria infection amongst febrile patients from the Malaria Elimination Demonstration Project in Mandla, Madhya Pradesh, India

Malaria positive

Malaria positive

P. falciparum

P. vivax

RDT

Microscopy

RDT

Microscopy

RDT

Microscopy

True positive

156

118

109

84

35

30

False negative

280

318

226

251

43

48

False positive

40

0

27

1

17

3

True negative

16,929

16,969

17,043

17,069

17,310

17,324

Sensitivity (95%CI)

35.8 (31.3–40.5)

27.1 (22.9–31.5)

32.5 (27.5–37.8)

25.1 (20.5–30.1)

44.9 (33.6–56.6)

38.5 (27.7–50.2)

Specificity (95%CI)

99.8 (99.7–99.8)

100 (100–100)

99.8 (99.8–99.9)

100 (100–100)

99.9 (99.8–99.9)

100 (99.9–100)

PPV (95%CI)

79.6 (73.3–85.0)

100 (96.9–100)

80.1 (72.4–86.5)

98.8 (93.6–100)

67.3 (52.9–79.7)

90.9 (75.7–98.1)

NPV (95%CI)

98.4 (98.2–98.6)

98.2 (97.9–98.4)

98.7 (98.5–98.9)

98.6 (98.4–98.7)

99.8 (99.7 -99.8)

99.7 (99.6–99.8)

  1. CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value