Fig. 1

Differentially expressed gene (DEG) analysis between malaria-infected and noninfected groups by using the MetaIntegrator R package. A–D, Plots of Meta Scores from the four cohort datasets comparing data from malaria-infected and noninfected groups were. E and F, The forest plots of DGEs LRRN3 and MMP9 among the different discovery cohorts. A positive standardized mean difference indicates a higher level while a negative standardized mean difference indicates a lower level in the malaria-infected group relative to the noninfected group. G. Heatmap of top 10 upregulated genes and top 10 downregulated genes. The gene expression levels are normalized across samples, and red (upregulated) and blue(downregulated) are colour-coded according to the right colour bar. Colour keys on the top of the heatmap denote sample type and dataset