Table 4 Distribution of pfdhfr and pfdhps combined haplotypes in Indonesia from 1996 to 2015

1

1996

West Papua

000RR0

0GE00

59R108R + 437G540E

2

1997

000RN0

0GE00

59R108N + 437G540E

3

1998

000RT0

0GE00

59R108T + 437G540E

4

1999

0GK00

5

2003

Central Java

V00RN0 & V00RT0

0GE00

6

2004

Indragiri Hilir, Riau

ANRNI + SAKAA

7

2004

West Nusa Tenggara

SAKAA + ANCSI

ANCNI + SAKAA, ANCSI + SGKAA

ANRNI + SAKAA, ANCSI + SGEAA

ANRNI + SGEAA (588f)

ANRNI + SGTGA

8

2004

Paser, East Kalimantan

ANCSI + SGKGA, ANCSI + SGEAA

ANRNI + SGEGA, ANRNI + SGTGA

ANRNL + SGTGA

9

2004

Pacitan, East Java

ANRNI + SGTGA, ANRNL + SGKGA, ANRNL + SGEAA

ANRNL + SGEGA

10

2004

Jayapura, Papua

ANCSI + SGEAA

11

2004

North Sumatera

000RN0

0GE00

12

2005

0GE00

13

2005

Indragiri Hilir, Riau

ANRNI + SAKAA

14

2005

West Nusa Tenggara

SAKAA + ANCSI

ANCNI + SAKAA, ANCSI + SGKAA

ANRNI + SAKAA, ANCSI + SGEAA

ANRNI + SGEAA (588f)

ANRNI + SGTGA

15

2005

Lampung

V00RN0 AND V00RT0

0GE00

16V/59R/108N + 437G/540E

16

2005

Nias, North Sumatera

V000RN0 AND V00RT0

0GE00

16V/59R/108T + 437G/540E

17

2005

Kutai, East Kalimantan

V00RN0 AND V00RT0

0GE00

18

2005

Paser, East Kalimantan

ANCSI + SGKGA, ANCSI + SGEAA

ANRNI + SGEGA, ANRNI + SGTGA

ANRNL + SGTGA

19

2005

Minahasa, North Sulawesi

V00RN0 AND V00RT0

0GE00

20

2005

Mamuju, West Sulawesi

V00RN0 AND V00RT0

0GE00

21

2005

Flores, East Nusa Tenggara

V00RN0 AND V00RT0

22

2005

Armopa, Papua

V00RN0 AND V00RT0

0GETG

16V/59R/108N + 437G/540E/581T (588G/F)

23

2005

Jayapura, Papua

ANCSI + SGEAA

24

2005

Kokap, Central Java

0GETG

16V/59R/108T + 437G/540E/581T (588G/F)

25

2005

Pacitan, East Java

ANRNI + SGTGA, ANRNL + SGKGA, ANRNL + SGEAA

ANRNL + SGEGA

26

2005

West Sumba District, East Nusa Tenggara

000RN0

SGKG0A

59R/108N + S436/437G/K540/581G/A613

27

2006

V00RN0 AND V00RT0

SGKG0A

28

2006

Indragiri Hilir, Riau

ANRNI + SAKAA

29

2006

West Nusa Tenggara

SAKAA + ANCSI

ANCNI + SAKAA, ANCSI + SGKAA

ANRNI + SAKAA, ANCSI + SGEAA

ANRNI + SGEAA (588f)

ANRNI + SGTGA

30

2006

Paser, East Kalimantan

ANCSI + SGKGA, ANCSI + SGEAA

ANRNI + SGEGA, ANRNI + SGTGA

ANRNL + SGTGA

31

2006

Pacitan, East Java

ANRNI + SGTGA, ANRNL + SGKGA, ANRNL + SGEAA

ANRNL + SGEGA

32

2006

Jayapura, Papua

ANCSI + SGEAA

33

2009

Indragiri Hilir, Riau

ANCSI + SGKAA

34

2009

Merangin, Jambi

ANRNL + SGEGA

35

2009

West Nusa Tenggara

ANRNI + SAKAA, ANCSI + SGEAA

36

2009

East Nusa Tenggara

ANRNI + SAKAA

37

2009

Banjar, South Kalimantan

ANCNI + SAKAA

ANCSI + SGKGA, ANCSI + SGEAA

ANRNI + SGEAA (588f),, ANRNL + SGKAA

ANRNI + SGEGA, ANRNI + SGTGA

ANRNL + SGTGA

38

2009

Seruyan, Central Kalimantan

ANRNI + SGTGA, ANRNL + SGKGA, ANRNL + SGEAA

ANRNL + SGEGA

39

2009

Gorontalo, Sulawesi

ANCSI + SGKAA

ANRNI + SGEAA (588f)

40

2009

Papua, Jayapura

ANCSI + SAKAA

ANCSI + SGEAA, ANRNI + SAKAA

ANRNI + SGEAA (588f)

41

2010

Indragiri Hilir, Riau

ANCSI + SGKAA

42

2010

Merangin, Jambi

ANRNL + SGEGA

43

2010

West Nusa Tenggara

ANRNI + SAKAA, ANCSI + SGEAA

44

2010

East Nusa Tenggara

ANRNI + SAKAA

45

2010

Banjar, South Kalimantan

ANCNI + SAKAA

ANCSI + SGKGA, ANCSI + SGEAA

ANRNI + SGEAA (588f),, ANRNL + SGKAA

ANRNI + SGEGA, ANRNI + SGTGA

ANRNL + SGTGA

46

2010

Seruyan, Central Kalimantan

ANRNI + SGTGA, ANRNL + SGKGA, ANRNL + SGEAA

ANRNL + SGEGA

47

2010

Gorontalo, Sulawesi

ANCSI + SGKAA

ANRNI + SGEAA (588f)

48

2010

Papua, Jayapura

ANCSI + SAKAA

ANCSI + SGEAA, ANRNI + SAKAA

ANRNI + SGEAA (588f)

49

2011

Indragiri Hilir, Riau

ANCSI + SGKAA

50

2011

Merangin, Jambi

ANRNL + SGEGA

51

2011

West Nusa Tenggara

ANRNI + SAKAA, ANCSI + SGEAA

52

2011

East Nusa Tenggara

ANRNI + SAKAA

53

2011

Banjar, South Kalimantan

ANCNI + SAKAA

ANCSI + SGKGA, ANCSI + SGEAA

ANRNI + SGEAA (588f),, ANRNL + SGKAA

ANRNI + SGEGA, ANRNI + SGTGA

ANRNL + SGTGA

54

2011

Seruyan, Central Kalimantan

ANRNI + SGTGA, ANRNL + SGKGA, ANRNL + SGEAA

ANRNL + SGEGA

55

2011

Gorontalo, Sulawesi

ANCSI + SGKAA

ANRNI + SGEAA (588f)

56

2011

Jayapura, Papua

ANCSI + SAKAA

ANCSI + SGEAA, ANRNI + SAKAA

ANRNI + SGEAA (588f)

57

2012

N

0

ANCSI + SAKAA

ANCSI + SGEAA, ANRNI + SAKAA

ANRNI + SGEAA (588f)

58

2012

Indragiri Hilir, Riau

ANCSI + SGKAA

59

2012

Merangin, Jambi

ANRNL + SGEGA

60

2012

West Nusa Tenggara

ANRNI + SAKAA, ANCSI + SGEAA

61

2012

East Nusa Tenggara

ANRNI + SAKAA

62

2012

Banjar, South Kalimantan

ANCNI + SAKAA

ANCSI + SGKGA, ANCSI + SGEAA

ANRNI + SGEAA (588f), ANRNL + SGKAA

ANRNI + SGEGA, ANRNI + SGTGA

ANRNL + SGTGA

63

2012

Seruyan, Central Kalimantan

ANRNI + SGTGA, ANRNL + SGKGA, ANRNL + SGEAA

ANRNL + SGEGA

64

2012

Gorontalo, Sulawesi

ANCSI + SGKAA

ANRNI + SGEAA (588f)

65

2012

South Kalimantan

N

GETG/F

66

2013

000RNL

67

2014

000RTL

68

2015

East Nusa Tenggara

VCNRN/T

16V/C50/N51/59R/108N/T + S436/A437/K540/581G/A613

VCNRS/T

16V/C50/N51/59R/108S/T + S436/A437/K540/581G/A613

VCNRS/N

16V/C50/N51/59R/108S/N + S436/A437/K540/581G/A613

VCNRS/S

16V/C50/N51/59R/108S + S436/A437/K540/581G/A613

VCNC/RN

16V/C50/N51/59C/R/108N + S436/A437/K540/581G/A613

69

2015

North Sulawesi

ACNRN/T

A16/C50/N51/59R/108N/T + S436/A437/K540/581G/A613

ACNRS/T

A16/C50/N51/59R/108S/T + S436/A437/K540/581G/A613

ACNRS/N

A16/C50/N51/59R/108S/N + S436/A437/K540/581G/A613

ACNRS/S

A16/C50/N51/59R/S108 + S436/A437/K540/581G/A613

70

2015

North Maluku

ACNRN/T

A16/C50/N51/59R/108N/T + S436/A437/K540/581G/A613

ACNRS/T

A16/C50/N51/59R/108S/T + S436/A437/K540/581G/A613

ACNRS/N

A16/C50/N51/59R/108S/N + S436/A437/K540/581G/A613

ACNRS/S

A16/C50/N51/59R/S108 + S436/A437/K540/581G/A613