Table 5 IC50 of phen and (1)–(4) that have antimalarial property on 20S proteasome at chymotrypsin-like (CT-L) site, trypsin-like (T-L) site and caspase-like (C-L) site after incubated with respective substrate in CO2 incubator for 30 min
Compound | IC50 of Pf3D7 (µM) | IC50 of Pf5202 (µM) | ||||
|---|---|---|---|---|---|---|
CT-L | T-L | C-L | CT-L | T-L | C-L | |
phen |  > 25 | 4.47 ± 0.60 |  > 25 |  > 25 | 1.79 ± 0.66 |  > 25 |
1 |  > 25 | 2.39 ± 0.13 |  > 25 |  > 25 | 1.62 ± 0.30 |  > 25 |
2 |  > 25 |  > 25 |  > 25 |  > 25 |  > 25 |  > 25 |
3 |  > 25 | 2.64 ± 0.35 |  > 25 |  > 25 | 1.72 ± 0.13 |  > 25 |
4 |  > 25 |  > 25 |  > 25 |  > 25 |  > 25 |  > 25 |
VR23 |  > 5 | 0.78 ± 0.11 |  > 5 |  > 5 | 0.86 ± 0.09 |  > 5 |