Fig. 3
Pathway analysis of genes significantly downregulated in schizont-infected hepatocytes in comparison to uninfected samples. (A) Most enriched ontology clusters for genes significantly downregulated in primary rhesus macaque hepatocytes infected with P. cynomolgi schizonts. The vertical dotted red line indicates adjusted Pvalues less than 0.05 (or − log10 (adj. Pvalue) greater than 1.3). The most significantly enriched term of each ontology clusters was selected as the cluster label. (B) Subset of representative terms were selected to generate a network of enriched ontology clusters. Terms are represented by circle nodes with colors that shows belonging to a specific cluster. Circles nodes with similarity scores > 0.3 are linked with edges. (C–L) Heat maps of log2 fold changes for the 25 most downregulated genes of selected ontology clusters. Data are shown for schizont-infected and uninfected bystander (negative) cells in comparison to uninfected samples. Some annotation terms are abbreviated or modified for a purpose of presentation