Fig. 4
Transcriptional response of schizont-infected hepatocytes in comparison to uninfected bystander cells. Most enriched ontology clusters for genes significantly upregulated (A) and downregulated (B) in hepatocytes infected with schizonts in comparison to uninfected bystander (negative) cells. Venn diagram analyses comparing upregulated (C) and downregulated (D) genes in schizont-infected hepatocytes vs. uninfected samples or in schizont-infected hepatocytes vs. negative cells. The 4 most enriched ontology clusters are shown for each subgroup of genes. Dotted red lines indicate adjusted Pvalues less than 0.05 (or − log10 (adj. Pvalue) greater than 1.3). Some annotation terms are abbreviated or modified for a purpose of presentation