Malaria patient spectrum representation in therapeutic clinical trials of uncomplicated malaria: a scoping review of the literature

Table 3 Comparison of the actual baseline characteristics with the criteria for eligibility

Criteria	No. of studies Reporting the criteria ranges/cut-off	No. of studies reporting criteria ranges/cut-off and baseline characteristics (%)^a	No. of studies reporting participant(s) outside the accepted inclusion ranges/cut-off (%)^b
Age	151	60 (40)	5 (8)
Parasitaemia	136	61 (45)	21 (34)
Haemoglobin level	55	10 (18)	4 (40)
Temperature	118	29 (25)	23 (80)
Weight	52	16 (31)	0 (0)
Haematocrit	4	0 (0)	–
Packed Cell Volume	5	1 (20)	1 (20)
Hepatic impairment (ALT)	3	0 (0)	–
Renal impairment (Creatinine)	1	0 (0)	–

^aThe percentages represent the proportion of the studies reporting criteria ranges/cut-off and baseline characteristics over the number of studies reporting the criteria
^bThe percentages represent the proportion of the studies enrolling at least a patient outside the accepted inclusion range/cut-off definition over the studies reporting criteria ranges/cut-off and baseline characteristics

ISSN: 1475-2875