Table 3 Lumefantrine concentration by treatment outcome among 94 individuals
From: Artemether-lumefantrine efficacy among adults on antiretroviral therapy in Malawi
Outcome | Number of observations | Mean lumefantrine at day 7 (SD) | Median lumefantrine at day 7 (IQR) | Lumefantrine level below 200 ng/ml, N(%) | OR for lumefantrine below 200 ng/ml (95% CI) |
|---|---|---|---|---|---|
Total | 94 | 247 (201) | 186 (95, 359) | 51 (54.3) | |
Treatment outcome** | |||||
Failure | 20 | 143 (108) | 91 (48, 231) | 13 (65.0) | 1.76 (0.63, 4.91) |
Success | 74 | 270 (208) | 190 (101, 378) | 38 (51.4) | Reference |
ART regimens*** | |||||
Efavirenz | 77 | 197 (144) | 170 (86, 277) | 47 (61.0) | 5.09 (1.52, 17.09) |
Non-efavirenz | 17 | 448 (270) | 383 (296, 666) | 4 (23.5) | Reference |
Desbutyl lumefantrine results | N detectable at day 7 (%) | N undetectable at day 7 (%) | OR for undetectable desbutyl lumefantrine (95% CI) | |
|---|---|---|---|---|
Treatment outcome | ||||
Failure | 20 | 7 (35.0) | 13 (65.0) | 3.05 (1.09, 8.56) |
Success | 74 | 46 (62.2) | 28 (37.8) | Reference |
ART regimens | ||||
Efavirenz | 77 | 48 (62.3) | 29 (37.7) | 0.25 (0.08, 0.79) |
Non-efavirenz | 17 | 5 (29.4) | 12 (70.6) | Reference |