Fig. 7
Metabolic reactions associated with the altered drug-sensitivity phenotypes of KAE609-treated and PA21A092-treated P. falciparum Dd2A211V parasites (Fig. 5A). These reactions conduct de novo synthesis of phosphatidylinositol (PtdIns), phosphatidylserine (PtdSer), phosphatidylethanolamine (PtdEth), and phosphatidylcholine (PtdCho). The two red cross marks represent myoinositol phosphate synthase and acetyl-CoA (accoa) carboxylase enzymes, which are essential for de novo synthesis of myoinositol phosphate (mip) and malonyl CoA (malCoA), respectively. These precursors are essential for phosphatidylinositol and fatty acid synthesis in P. falciparum. The dashed lines indicate the presence of multiple enzymes, while solid lines indicate the presence of an individual enzyme. αkg α-ketoglutarate, adn, adenosine, ahcys S-adenosylhomocysteine, cdpchol cytidine diphosphocholine, cdpdag cytidine diphosphate diacylglycerol, CoA coenzyme A, dag diacylglycerol, dhap dihydroxyacetone phosphate, FA fatty acid; fdp fructose diphosphate, fum fumarate, g3p glyceraldehyde 3-phosphate, g6p glucose 6-phosphate, glyc3p glycerol 3-phosphate, hco3 bicarbonate, hcys homocysteine, hxan hypoxanthine, ins inosine, mal L-malate, malACP malonyl acyl carrier protein, met L-methionine, mi myoinositol, oaa oxaloacetate, PA phosphatidic acid, pep phosphoenolpyruvate, pyr pyruvate, sam S-adenosylmethionine, ser-L L-serine