Table 1 Gene sets altered in KAE609-treated and PA21A092-treated mutant parasites
Gene set description | Ngene | Percentage of altered genes (%) | |||||
|---|---|---|---|---|---|---|---|
Dd2A211V | Dd2 | NF54 | |||||
KA09a | PA92a | PA92b | HXNc | APId | FOSe | ||
Respiratory chain proteins | 48 | 18.8 | 22.9 | 8.3 | 0.0 | 0.0 | 2.1 |
Mitochondrion electron flow | 37 | 16.2 | 18.9 | 10.8 | 2.7 | 0.0 | 0.0 |
Biogenesis of cytochrome oxidase | 29 | 13.8 | 6.9 | 6.9 | 3.4 | 0.0 | 3.4 |
Copper transport | 21 | 28.6 | 14.3 | 14.3 | 4.8 | 0.0 | 0.0 |
Centriole proteins | 21 | 19.0 | 23.8 | 14.3 | 0.0 | 0.0 | 4.8 |
Cytochrome C biogenesis | 18 | 22.2 | 22.2 | 11.1 | 5.6 | 0.0 | 0.0 |
Mitochondrial disulphide relay system | 13 | 15.4 | 7.7 | 15.4 | 7.7 | 0.0 | 0.0 |
Lysine methylation and demethylation | 11 | 18.2 | 18.2 | 9.1 | 0.0 | 0.0 | 0.0 |