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Table 2 Characteristics for patient profiles analysed in stage 1 of the WWARN PCEa

From: Quantification of parasite clearance in Plasmodium knowlesi infections

Characteristics

All patients

(n = 714 patients)

Successful analysis

(n = 678 patients)

Unsuccessful analysis

(n = 36 patients)

Number of parasite measurements

 Median, IQR

5, 5–6

6, 5–7

3, 3–3

 Range

3–14

3–14

3–5

 < 3

0

0

0

 3

37 (5.2%)

2 (0.3%)

35 (97.2%)

 4

107 (15%)

107 (15.8%)

0

 5

217 (30.4%)

216 (31.9%)

1 (2.8%)

 6

182 (25.5%)

182 (26.8%)

0

 7

110 (15.4%)

110 (16.2%)

0

 ≥ 8

61 (8.5%)

61 (9%)

0

Sex

 Female

135 (18.9%)

128 (18.9%)

7 (19.4%)

 Male

579 (81.1%)

550 (81.1%)

29 (80.6%)

Age (years)

 Median, IQR

35, 24–49

34, 23–48

37, 23–44.5

 Range

3–96

3–96

14–68

Weight (kg)

 Median, IQR

58, 50–67

58, 50.4–67

59, 51.5–68

 Range

11–118

11–118

35–80.5

Previous malaria

 No

511 (71.6%)

489 (72.1%)

22 (61.1%)

 Yes

203 (28.4%)

189 (27.9%)

14 (38.9%)

Days of preceding fever

 Median, IQR

4, 3–7

4, 3–7

4, 3–7

 Range

0–44b

0–44c

2–14d

Initial parasitaemia (/μL of blood)

 Median, IQR

1898, 463–6276

2056, 533–6398

127, 56–555

 Range

28–325,294

28–325,294

28–16,748

Treatment

Uncomplicated malaria

   

 Artemether–lumefantrine

320 (44.8%)

301 (44.3%)

19 (52.8%)

 Artesunate–mefloquine

115 (16.1%)

111 (16.4%)

4 (11%)

 Chloroquine

176 (24.7%)

174 (25.7%)

2 (5.6%)

Severe malaria

   

 Artemether–lumefantrine followed by artesunate (intravenous)

16 (2.2%)

15 (2.2%)

1 (2.8%)

 Artesunate (intravenous) followed by artemether–lumefantrine

87 (12.2%)

77 (11.4%)

10 (27.8%)

  1. aWorldwide Antimalarial Resistance Network’s Parasite Clearance Estimator
  2. IQR: inter-quartile range; kg: kilograms; μL: microlitre
  3. b18 patients did not have data for days of preceding fever
  4. c2 patients did not have data for days of preceding fever
  5. d16 patients did not have data for days of preceding fever