From: Quantification of parasite clearance in Plasmodium knowlesi infections
Characteristics | All patients (n = 714 patients) | Successful analysis (n = 678 patients) | Unsuccessful analysis (n = 36 patients) |
---|---|---|---|
Number of parasite measurements | |||
 Median, IQR | 5, 5–6 | 6, 5–7 | 3, 3–3 |
 Range | 3–14 | 3–14 | 3–5 |
 < 3 | 0 | 0 | 0 |
 3 | 37 (5.2%) | 2 (0.3%) | 35 (97.2%) |
 4 | 107 (15%) | 107 (15.8%) | 0 |
 5 | 217 (30.4%) | 216 (31.9%) | 1 (2.8%) |
 6 | 182 (25.5%) | 182 (26.8%) | 0 |
 7 | 110 (15.4%) | 110 (16.2%) | 0 |
 ≥ 8 | 61 (8.5%) | 61 (9%) | 0 |
Sex | |||
 Female | 135 (18.9%) | 128 (18.9%) | 7 (19.4%) |
 Male | 579 (81.1%) | 550 (81.1%) | 29 (80.6%) |
Age (years) | |||
 Median, IQR | 35, 24–49 | 34, 23–48 | 37, 23–44.5 |
 Range | 3–96 | 3–96 | 14–68 |
Weight (kg) | |||
 Median, IQR | 58, 50–67 | 58, 50.4–67 | 59, 51.5–68 |
 Range | 11–118 | 11–118 | 35–80.5 |
Previous malaria | |||
 No | 511 (71.6%) | 489 (72.1%) | 22 (61.1%) |
 Yes | 203 (28.4%) | 189 (27.9%) | 14 (38.9%) |
Days of preceding fever | |||
 Median, IQR | 4, 3–7 | 4, 3–7 | 4, 3–7 |
 Range | 0–44b | 0–44c | 2–14d |
Initial parasitaemia (/μL of blood) | |||
 Median, IQR | 1898, 463–6276 | 2056, 533–6398 | 127, 56–555 |
 Range | 28–325,294 | 28–325,294 | 28–16,748 |
Treatment | |||
Uncomplicated malaria | Â | Â | Â |
 Artemether–lumefantrine | 320 (44.8%) | 301 (44.3%) | 19 (52.8%) |
 Artesunate–mefloquine | 115 (16.1%) | 111 (16.4%) | 4 (11%) |
 Chloroquine | 176 (24.7%) | 174 (25.7%) | 2 (5.6%) |
Severe malaria | Â | Â | Â |
 Artemether–lumefantrine followed by artesunate (intravenous) | 16 (2.2%) | 15 (2.2%) | 1 (2.8%) |
 Artesunate (intravenous) followed by artemether–lumefantrine | 87 (12.2%) | 77 (11.4%) | 10 (27.8%) |