Fig. 2
Plasmodium falciparum susceptibility to rhinacanthin analogues and standard anti-malarials. Scatter plots show IC50 to mefloquine (MQ), quinine (QN), chloroquine (CQ), atovaquone (ATQ), and rhinacanthin analogues 1 (RA1) and 2 (RA2) for 4 fresh field isolates (single experiment) and reference laboratory strains (2–5 replicate experiments). Field isolates and reference laboratory strains are colour-coded as in the legend, drug resistant profiles of reference strains were indicated in the legend. Bars represent the median IC50 values of field isolates, the median values of field isolates and reference strains are also indicated above the dot plot, accordingly. The red dashed lines indicate established resistance thresholds from the literature (IC50 to MQ > 24 nM, IC50 to QN > 351 nM, IC50 to CQ > 85 nM, and ATQ > 1,900 nM).